Evaluation of Eruption of Permanent Teeth in Beagle Dog Extraction Sites Filled with Carbonate Apatite-Reference-Cited by-同舟云学术

Evaluation of Eruption of Permanent Teeth in Beagle Dog Extraction Sites Filled with Carbonate Apatite

Published:2023-12-13 Issue:24 Volume:16 Page:7624
ISSN:1996-1944
Container-title:Materials
language:en
Short-container-title:Materials

Author:

Kibe Toshiro¹^ORCID,Nakazono Kenta¹,Yamashita Kaoru²,Tada Ryohei¹,Ono Yusuke¹,Ishihata Kiyohide¹

Affiliation:

1. Department of Oral and Maxillofacial Surgery, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan

2. Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan

Abstract

Autologous bone grafting is the primary method for treating alveolar clefts. However, bone grafting materials are desired as alternatives to autogenous bone to reduce surgical invasiveness. Here, we present an animal study evaluating the effect of carbonate apatite (CA) on the spontaneous eruption of permanent teeth. The bone grafting materials included CA, natural bovine bone (BB), and hydroxyapatite (HA). In 15 8-week-old male beagle dogs, the left mandibular deciduous premolars (DP) two and three were extracted and subsequently filled with CA, BB, and HA. The animals were euthanized after a predetermined number of days, and samples were collected for microcomputed tomography and histological evaluation. Spontaneous eruption of the succeeding permanent teeth (P3 and P4) was observed in the CA group at 14 weeks. Delayed eruption of the succeeding permanent teeth was observed in the BB and HA groups. CA could serve as a viable alternative to autogenous bone for treating alveolar clefts.

Funder

GC Corporation

JSPS KAKENHI Grant-in-Aid for Scientific Researc

Publisher

MDPI AG

Subject

General Materials Science

Link

https://www.mdpi.com/1996-1944/16/24/7624/pdf

Reference37 articles.

1. National population-based estimates for major birth defects, 2010–2014;Mai;Birth Defects Res.,2019

2. National Birth Defects Prevention Study. Use of topiramate in pregnancy and risk of oral clefts;Margulis;Am. J. Obstet. Gynecol.,2012

3. Secondary bone grafting of residual alveolar and palatal clefts;Boyne;J. Oral Surg.,1972

4. Combined orthodontic-surgical management of residual palato-alveolar cleft defects;Boyne;Am. J. Orthod.,1976

5. Guo, J., Li, C., Zhang, Q., Wu, G., Deacon, S.A., Chen, J., Hu, H., Zou, S., and Ye, Q. (2011). Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate. Cochrane Database Syst. Rev., CD008050.