Contribution of smFRET to Chromatin Research

Author:

Sengupta Bhaswati1ORCID,Huynh Mai2

Affiliation:

1. Wexner Medical Center, Ohio State University, Columbus, OH 43210, USA

2. Department of Chemistry, Pennsylvania State University, University Park, PA 16801, USA

Abstract

Chromatins are structural components of chromosomes and consist of DNA and histone proteins. The structure, dynamics, and function of chromatins are important in regulating genetic processes. Several different experimental and theoretical tools have been employed to understand chromatins better. In this review, we will focus on the literatures engrossed in understanding of chromatins using single-molecule Förster resonance energy transfer (smFRET). smFRET is a single-molecule fluorescence microscopic technique that can furnish information regarding the distance between two points in space. This has been utilized to efficiently unveil the structural details of chromatins.

Publisher

MDPI AG

Subject

Materials Chemistry,Economics and Econometrics,Media Technology,Forestry

Reference88 articles.

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5. The renaissance of fluorescence resonance energy transfer;Selvin;Nat. Struct. Biol.,2000

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