Compliance with a Healthful Plant-Based Diet Is Associated with Kidney Function in Patients with Autosomal Dominant Polycystic Kidney Disease

Author:

Heo Sumin1,Han Miyeun2,Ryu Hyunjin3,Kang Eunjeong3ORCID,Kim Minsang3ORCID,Ahn Curie2,Yang Soo Jin1ORCID,Oh Kook-Hwan3

Affiliation:

1. Department of Food and Nutrition, Seoul Women’s University, Seoul 01797, Republic of Korea

2. Department of Internal Medicine, National Medical Center, Seoul 04564, Republic of Korea

3. Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic kidney disorder with multiple cyst formation that progresses to chronic kidney disease (CKD) and end-stage kidney disease. Plant-based diets have attracted considerable attention because they may prevent CKD development. This study investigated whether adherence to a plant-based diet is associated with kidney function in patients with ADPKD. The overall plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI) were calculated using dietary intake data. Among 106 ADPKD patients, 37 (34.91%) were classified as having advanced CKD (eGFR < 60 mL/min/1.73 m2). The overall PDI and hPDI were lower, but the uPDI was higher in patients with advanced CKD than in those with early CKD. The hPDI was negatively correlated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Moreover, the hPDI was inversely associated with advanced CKD [odds ratio (OR): 0.117 (95% confidence interval (CI): 0.039–0.351), p < 0.001], and the uPDI was positively associated with advanced CKD [OR: 8.450 (95% CI: 2.810–25.409), p < 0.001]. The findings of the current study demonstrate that greater adherence to a healthful plant-based diet is associated with improved kidney function in ADPKD patients.

Funder

Korea National Institute of Health

Seoul Women’s University

Publisher

MDPI AG

Reference31 articles.

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