Alcohol Consumption and a Decline in Glomerular Filtration Rate: The Japan Specific Health Checkups Study
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Published:2023-03-22
Issue:6
Volume:15
Page:1540
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ISSN:2072-6643
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Container-title:Nutrients
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language:en
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Short-container-title:Nutrients
Author:
Kimura Yoshiki12, Yamamoto Ryohei13ORCID, Shinzawa Maki1, Aoki Katsunori1, Tomi Ryohei1, Ozaki Shingo1ORCID, Yoshimura Ryuichi3ORCID, Shimomura Akihiro2, Iwatani Hirotsugu2, Isaka Yoshitaka1ORCID, Iseki Kunitoshi4, Tsuruya Kazuhiko4, Fujimoto Shouichi4ORCID, Narita Ichiei4, Konta Tsuneo4ORCID, Kondo Masahide4, Kasahara Masato4, Shibagaki Yugo4, Asahi Koichi4, Watanabe Tsuyoshi4ORCID, Yamagata Kunihiro4, Moriyama Toshiki1345
Affiliation:
1. Department of Nephrology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan 2. Department of Nephrology, National Hospital Organization Osaka National Hospital, Osaka 540-0006, Japan 3. Health and Counseling Center, Osaka University, Toyonaka 560-0043, Japan 4. The Japan Specific Health Checkups (J-SHC) Study Group, Fukushima, Japan 5. Health Promotion and Regulation, Department of Health Promotion Medicine, Osaka University Graduate School of Medicine, Toyonaka 560-0043, Japan
Abstract
Previous studies have reported conflicting results on the clinical impact of alcohol consumption on the glomerular filtration rate (GFR). This retrospective cohort study aimed to assess the dose-dependent association between alcohol consumption and the slope of the estimated GFR (eGFR) in 304,929 participants aged 40–74 years who underwent annual health checkups in Japan between April 2008 and March 2011. The association between the baseline alcohol consumption and eGFR slope during the median observational period of 1.9 years was assessed using linear mixed-effects models with the random intercept and random slope of time adjusting for clinically relevant factors. In men, rare drinkers and daily drinkers with alcohol consumptions of ≥60 g/day had a significantly larger decline in eGFR than occasional drinkers (difference in multivariable-adjusted eGFR slope with 95% confidence interval (mL/min/1.73 m2/year) of rare, occasional, and daily drinkers with ≤19, 20–39, 40–59, and ≥60 g/day: −0.33 [−0.57, −0.09], 0.00 [reference], −0.06 [−0.39, 0.26], −0.16 [−0.43, 0.12], −0.08 [−0.47, 0.30], and −0.79 [−1.40, −0.17], respectively). In women, only rare drinkers were associated with lower eGFR slopes than occasional drinkers. In conclusion, alcohol consumption was associated with the eGFR slope in an inverse U-shaped fashion in men but not in women.
Funder
Japan Agency for Medical Research and Development Ministry of Health, Labour and Welfare of Japan
Subject
Food Science,Nutrition and Dietetics
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