Abstract
In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established methods are available. However, the breeding of immunodeficient mice is considered an experiment requiring a permit, even if no pain, suffering or harm is observed under scientifically required defined hygienic housing conditions, as determined by established methods of severity assessment. This seems contradictory and leads to uncertainty among scientists. With this commentary, we would like to shed light on this topic from different perspectives and propose a solution in terms of individualized severity assessment and approval procedures.
Subject
General Veterinary,Animal Science and Zoology
Reference16 articles.
1. Untersuchung ueber die intracellulare verdauung bei wirbellosen thieren [German];Metschnikoff;Arb. Zool. Inst. Univ. Wien. Zool. Stat. Triest,1884
2. CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE
3. Delineation of the Thymic and Bursal Lymphoid Systems in the Chicken
4. Über das Zustandekommen der Diphtherie-Immunität und der Tetanus-Immunität bei Thieren;Behring;Dtsch. Wochenschr.,1890
5. Continuous cultures of fused cells secreting antibody of predefined specificity
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献