Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review-Reference-Cited by-同舟云学术

Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review

Published:2024-08-14 Issue:16 Volume:13 Page:4794
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Jeyaraman Naveen¹^ORCID,Migliorini Filippo²³^ORCID,Murugan Shrideavi⁴,Ramasubramanian Swaminathan⁵^ORCID,Balaji Sangeetha⁵,Maffulli Nicola⁶⁷⁸^ORCID,Jeyaraman Madhan¹^ORCID

Affiliation:

1. Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India

2. Department of Orthopaedic and Trauma Surgery, Academic Hospital of Bolzano (SABES-ASDAA), 39100 Bolzano, Italy

3. Department of Life Sciences, Health, and Health Professions, Link Campus University, 00165 Rome, Italy

4. Department of Orthopaedics, Government Tirunelveli Medical College and Hospital, Tirunelveli 627002, Tamil Nadu, India

5. Department of Orthopaedics, Government Medical College, Omandurar Government Estate, Chennai 600002, Tamil Nadu, India

6. Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185 Roma, Italy

7. School of Pharmacy and Bioengineering, Keele University Faculty of Medicine, Stoke on Trent ST4 7QB, UK

8. Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Mile End Hospital, Queen Mary University of London, London E1 4DG, UK

Abstract

Metamizole, or dipyrone, has been used for decades as a non-narcotic analgesic, providing pain relief from musculoskeletal disorders and antipyretic and antispasmolytic properties. Despite being in use since the 1920s, its mechanism of action still needs to be discovered. Despite causing fewer adverse effects when compared to other analgesics, its harmful effects on the blood and lack of evidence regarding its teratogenicity make the usage of the drug questionable, which has led to it being removed from the drug market of various countries. This narrative review aims to provide a detailed insight into the mechanism of action and efficacy, comparing its effectiveness and safety with other classes of drugs and the safety profile of metamizole.

Publisher

MDPI AG

Link

https://www.mdpi.com/2077-0383/13/16/4794/pdf

Reference91 articles.

1. GBD 2021 Low Back Pain Collaborators (2023). Global, Regional, and National Burden of Low Back Pain, 1990–2020, Its Attributable Risk Factors, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol., 5, e316–e329.

2. Mechanisms and Efficacy of Heat and Cold Therapies for Musculoskeletal Injury;Malanga;Postgrad. Med.,2015

3. Musculoskeletal Disorders: OWAS Review;Ind. Health,2017

4. Risk Factors for Work-Related Musculoskeletal Disorders: A Systematic Review of Recent Longitudinal Studies;Vieira;Am. J. Ind. Med.,2010

5. The Assessment of Musculoskeletal Pain;Hawker;Clin. Exp. Rheumatol.,2017