Radiographic Knee Osteoarthritis Is a Risk Factor for the Development of Dementia: Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study-Reference-Cited by-同舟云学术

Radiographic Knee Osteoarthritis Is a Risk Factor for the Development of Dementia: Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study

Published:2024-08-22 Issue:16 Volume:13 Page:4956
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Endo Yuji¹^ORCID,Kobayashi Hiroshi¹^ORCID,Watanabe Kazuyuki¹^ORCID,Otani Koji¹^ORCID,Otoshi Kenichi²,Numazaki Hironori²,Sekiguchi Miho¹^ORCID,Sato Mari³^ORCID,Nikaido Takuya¹^ORCID,Ono Rei⁴,Konno Shin-ichi¹,Matsumoto Yoshihiro¹

Affiliation:

1. Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan

2. Department of Sports Medicine, Fukushima Medical University, Fukushima 960-1295, Japan

3. Department of Rehabilitation Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan

4. Department of Physical Activity Research, National Institute of Biomedical Innovation, Health, and Nutrition—National Institute of Health and Nutrition, Osaka 566-0002, Japan

Abstract

Objective: Osteoarthritis is linked to dementia, but no longitudinal studies have established this connection. This prospective cohort study from the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) aimed to determine if knee osteoarthritis (KOA) independently predicts dementia in adults aged 65 and above. Methods: Participants were classified by the Kellgren–Laurence scale into no/minimal KOA (grades 0 and I) and definitive KOA (grade II or higher). We analyzed dementia incidence from 2009 to 2015 using long-term care insurance data, adjusting for age, sex, vascular risks, depressive symptoms, and activity levels. Results: Out of 1089 participants (58.9% female, average age 72.5), 72.0% had definitive KOA. Dementia occurrence was significantly higher in the definitive group (8.4%) compared to the no/minimal group (3.0%) (p < 0.001). A log-rank test and Cox regression analysis confirmed these findings, showing an adjusted hazard ratio of 2.29 (confidence interval: 1.12–4.68) for dementia in those with definitive KOA. Conclusions: These results suggest that KOA is a significant risk factor for dementia, highlighting the importance of addressing contributing factors in KOA patients to potentially slow the progression of dementia.

Publisher

MDPI AG

Link

https://www.mdpi.com/2077-0383/13/16/4956/pdf

Reference42 articles.

1. (2024, February 29). World Social Report 2023: Leaving No One behind in an Aging World. Department of Economic and Social Affairs. Available online: https://www.un.org/development/desa/dspd/wp-content/uploads/sites/22/2023/01/WSR_2023_Chapter_Key_Messages.pdf.

2. Mathers, C.D., and Loncar, D. (2006). Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med., 3.

3. The prevalence of dementia: A systematic review and meta-analysis;Cao;J. Alzheimers Dis.,2020

4. Dementia Statistics (2024, February 29). Alzheimer’s Disease International. Available online: https://www.alzint.org/about/dementia-facts-figures/dementia-statistics/.

5. (2024, February 29). The Economic Impact of Dementia Alzheimer’s Research, U.K. Available online: https://dementiastatistics.org/statistics/the-economic-impact-of-dementia.