Abstract
The recently discovered high-level natural background radiation area (HBRA) of Mamuju in Indonesia provides a unique opportunity to study the biological effects of chronic low-dose radiation exposure on a human population. The mean total effective dose in the HBRA was approximately 69.6 mSv y−1 (range: 47.1 to 115.2 mSv y−1), based on a re-evaluation of the individual radiation exposure dose; therefore, proteomic analyses of serum components and oxidative modification profiling of residents living in the HBRA were reconducted using liquid chromatography-tandem mass spectrometry. The analysis of the oxidative modification sequences of human serum albumin revealed significant moderate correlations between the radiation dose and the modification of 12 sequences, especially the 111th methionine, 162nd tyrosine, 356th tyrosine, and 470th methionine residues. In addition, a dose-dependent variation in 15 proteins of the serum components was detected in the serum of residents exposed to chronic low-dose radiation. These findings suggest that the alterations in the expression of specific proteins and the oxidative modification responses of serum albumin found in exposed humans may be important indicators for considering the effects of chronic low-dose radiation exposure on living organisms, implying their potential utility as biomarkers of radiation dose estimation.
Funder
Japan Society for the Promotion of Science
Hirosaki University Institutional Research
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference46 articles.
1. Evaluation of natural chronic low dose radiation exposure on telomere length and transcriptional response of shelterin complex in individuals residing in Kerala coast, India;Saini;Mutat. Res.,2022
2. Human exposure to high natural background radiation: What can it teach us about radiation risks?;Hendry;J. Radiol Prot.,2009
3. Radiometric Mapping for Naturally Occurring Radioactive Materials (NORM) Assessment in Mamuju, West Sulawesi;Syaeful;Atom. Indones,2014
4. Cytogenetic and Molecular Damages in Blood Lymphocyte of Inhabitants Living in High Level Natural Radiation Area (HLNRA) of Botteng Village, Mamuju, West Sulawesi, Indonesia;Syaifudin;Radiat Environ. Med.,2018
5. Study of γ-H2AX as DNA double strand break biomarker in resident living in high natural radiation area of Mamuju, West Sulawesi;Basri;J. Environ. Radioact.,2017