Inhibition of Tumor Growth and Modulation of Antioxidant Activity of Rhodoxanthin Isolated from Taxus baccata Aril against B16F10 Murine Malignant Melanoma
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Published:2022-11-16
Issue:11
Volume:11
Page:2264
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ISSN:2076-3921
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Container-title:Antioxidants
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language:en
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Short-container-title:Antioxidants
Author:
Dumitraş Daria-AntoniaORCID, Dreanca Alexandra Iulia, Pall EmokeORCID, Gal Adrian Florin, Rus VasileORCID, Morohoschi Andreea Georgiana, Cotul Mihaela, Nan Monica Irina, Andrei SandaORCID
Abstract
Malignant melanoma is the most aggressive type of skin cancer, and due to the numerous limitations of current treatment methods, there is an urgent need to develop novel approaches for both the prevention and treatment of malignant melanoma, with research-oriented bioactive substances representing a notable first step. The current study decided to expand on previous rhodoxanthin research by investigating the possible anti-tumor effect as well as the effect on the antioxidant status in the case of murine melanoma in an experimental model. The 21-day study was carried out on female C57BL/6J mice. On the first day of the experiment, they were subcutaneously inoculated with 106 B16F10 cells and were given rhodoxanthin orally until the end of the study. Rhodoxanthin supplementation significantly reduced tumor growth (42.18%) and weight (15.74%). Furthermore, the epidermal growth factor (EGF) activity was reduced and the concentration of 8-OHdG dropped in the treated melanoma-bearing mice compared to the untreated ones, demonstrating the role of rhodoxanthin in slowing tumor growth, one of the mechanisms being the reduction of EGF level and the decrease of DNA oxidation. The administration of rhodoxanthin determined variations in antioxidant enzymes, both at the plasma level and at the tissue level.
Funder
Romanian Ministry of Research, Innovation and Digitalization USAMV CN
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference47 articles.
1. Gastaldello, G.H., Cazeloto, A.C.V., Ferreira, J.C., Rodrigues, D.M., Bastos, J.K., Campo, V.L., Zoccal, K.F., and Tefé-Silva, C. (2021). Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10. Medicines, 8. 2. Lesões cutâneas malignas e pré-malignas: Conhecimentos, hábitos e campanhas de prevenção solar;Acta Paul. Enferm.,2015 3. Dumitraș, D.-A., and Andrei, S. (2022). Recent Advances in the Antiproliferative and Proapoptotic Activity of Various Plant Extracts and Constituents against Murine Malignant Melanoma. Molecules, 27. 4. Pinello, K., Pires, I., Castro, A.F., Carvalho, P.T., Santos, A., de Matos, A., Queiroga, F., Canadas-Sousa, A., Dias-Pereira, P., and Catarino, J. (2022). Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, Topography and Main Morphologies. Data from Vet-OncoNet. Vet. Sci., 9. 5. Meuten, D.J. (2002). Tumors in Domestic Animals, Blackwell. [4th ed.].
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