Affiliation:
1. iBB-Institute for Bioengineering and Biosciences and i4HB-Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
2. Bioengineering Department, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
Abstract
Cancer is a result of abnormal cell proliferation. This pathology is a serious health problem since it is a leading cause of death worldwide. Current anti-cancer therapies rely on surgery, radiation, and chemotherapy. However, these treatments still present major associated problems, namely the absence of specificity. Thus, it is urgent to develop novel therapeutic strategies. Nanoparticles, particularly dendrimers, have been paving their way to the front line of cancer treatment, mostly for drug and gene delivery, diagnosis, and disease monitoring. This is mainly derived from their high versatility, which results from their ability to undergo distinct surface functionalization, leading to improved performance. In recent years, the anticancer and antimetastatic capacities of dendrimers have been discovered, opening new frontiers to dendrimer-based chemotherapeutics. In the present review, we summarize the intrinsic anticancer activity of different dendrimers as well as their use as nanocarriers in cancer diagnostics and treatment.
Funder
Fundação para a Ciência e a Tecnologia
Research Unit iBB-Institute for Bioengineering and Biosciences
Associate Laboratory i4HB-Institute for Health and Bioeconomy
OSTEGLUTIS
FCT PhD fellowship
FCT contract
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference113 articles.
1. Review of cancer from perspective of molecular;Hassanpour;J. Cancer Res. Pract.,2017
2. World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015;McGuire;Adv. Nutr.,2016
3. Environmental factors inducing human cancers;Parsa;Iran J. Public Health,2012
4. Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy;Eur. J. Pharm. Biopharm,2015
5. Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor;Quintana;Pharm. Res.,2002
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