Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer?-Reference-Cited by-同舟云学术

Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer?

Published:2023-03-18 Issue:6 Volume:24 Page:5824
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Majewski Marek¹,Torres Kamil²,Mertowska Paulina³^ORCID,Mertowski Sebastian³^ORCID,Korona-Głowniak Izabela⁴^ORCID,Korulczyk Jan²,Zgodziński Witold⁵,Grywalska Ewelina³^ORCID

Affiliation:

1. 2nd Department of General, Gastrointestinal Surgery and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, 20-081 Lublin, Poland

2. Chair and Department of Didactics and Medical Simulation, Medical University of Lublin, 20-093 Lublin, Poland

3. Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland

4. Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland

5. 1st Department of General and Transplant Surgery and Clinical Nutrition, Medical University of Lublin, 20-090 Lublin, Poland

Abstract

Gastric cancer is one of the five most common types of cancer worldwide. Due to the heterogeneous course and the involvement of many risk factors, its treatment and diagnosis is an important challenge for modern medicine. Recent studies have emphasized the i role of Toll-like receptors (TLRs) expressed on selected cells of the immune system in the pathogenesis of gastric cancer. The aim of this study was to determine the prevalence of TLR2 on T lymphocytes, B lymphocytes, monocytes, and dendritic cells in patients diagnosed with gastric cancer, with particular emphasis on the stage of the disease. Based on the obtained results, we have shown that patients with gastric cancer are characterized by a higher percentage of all tested populations of peripheral blood immune cells expressing TLR2 in relation to patients from the control group. Moreover, a detailed analysis of the collected results showed a significant link between TLR2 and the stage of the disease.

Funder

Medical University of Lublin

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/6/5824/pdf

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