8-Oxoguanine DNA Glycosylase 1 Upregulation as a Risk Factor for Obesity and Colorectal Cancer

Author:

Pilo Jesús12ORCID,García-Flores Libia Alejandra12ORCID,Clemente-Postigo Mercedes12345,Arranz-Salas Isabel67,Alcaide Julia8ORCID,Ramos-Fernandez Maria9,Lozano José10,Boughanem Hatim12311ORCID,Kompella Pallavi1212,Macías-González Manuel123ORCID

Affiliation:

1. Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, Spain

2. Institute of Biomedical Research in Malaga (IBIMA)-Bionand Platform, University of Malaga, 29590 Malaga, Spain

3. Spanish Biomedical Research Center in Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, 28029 Madrid, Spain

4. Department of Cell Biology, Genetics, and Physiology, Faculty of Science, University of Malaga, 29590 Malaga, Spain

5. Department of Cell Biology, Physiology and Immunology, Maimónides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, 14004 Córdoba, Spain

6. Division of Anatomical Pathology, Hospital Universitario Virgen de la Victoria, 29010 Malaga, Spain

7. Department of Human Physiology, Human Histology, Anatomical Pathology and Physical Education, University of Malaga, 29010 Malaga, Spain

8. Medical Oncology Intercenter Unit, Regional and Virgen de la Victoria University Hospitals, IBIMA, 29010 Málaga, Spain

9. Unidad de Gestion Clinica Cirugía General y del Aparato Digestivo, Virgen de la Victoria University, 29010 Malaga, Spain

10. Department of Biochemistry and Molecular Biology, University of Malaga, 29010 Málaga, Spain

11. Unidad de Gestión Clinica Medicina Interna, Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Córdoba, Reina Sofia University Hospital, University of Córdoba, 14004 Córdoba, Spain

12. Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA

Abstract

DNA damage has been extensively studied as a potentially helpful tool in assessing and preventing cancer, having been widely associated with the deregulation of DNA damage repair (DDR) genes and with an increased risk of cancer. Adipose tissue and tumoral cells engage in a reciprocal interaction to establish an inflammatory microenvironment that enhances cancer growth by modifying epigenetic and gene expression patterns. Here, we hypothesize that 8-oxoguanine DNA glycosylase 1 (OGG1)—a DNA repair enzyme—may represent an attractive target that connects colorectal cancer (CRC) and obesity. In order to understand the mechanisms underlying the development of CRC and obesity, the expression and methylation of DDR genes were analyzed in visceral adipose tissue from CRC and healthy participants. Gene expression analysis revealed an upregulation of OGG1 expression in CRC participants (p < 0.005) and a downregulation of OGG1 in normal-weight healthy patients (p < 0.05). Interestingly, the methylation analysis showed the hypermethylation of OGG1 in CRC patients (p < 0.05). Moreover, expression patterns of OGG1 were found to be regulated by vitamin D and inflammatory genes. In general, our results showed evidence that OGG1 can regulate CRC risk through obesity and may act as a biomarker for CRC.

Funder

“Centro de Investigacion Biomédica en Red Fisiopatología de la Obesidad y Nutricion”

European Regional Development Fund

ISCIII

Consejeria Universidad, Investigacion e Innovacion Junta de Andalucia

Fulbright Usjunir Scholar Grant

“Plan Propio IBIMA 2020 A.1 Contratos predoctorales”

Instituto de Salud Carlos III—Madrid

“Servicio Andaluz de Salud, Junta de Andalucia”

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3