Wavelength-Dependent Effects of Photobiomodulation for Wound Care in Diabetic Wounds
-
Published:2023-03-20
Issue:6
Volume:24
Page:5895
-
ISSN:1422-0067
-
Container-title:International Journal of Molecular Sciences
-
language:en
-
Short-container-title:IJMS
Author:
Dungel Peter12, Sutalo Sanja12, Slezak Cyrill123ORCID, Keibl Claudia12, Schädl Barbara124ORCID, Schnidar Harald5ORCID, Metzger Magdalena12, Meixner Barbara12, Hartmann Jaana12, Oesterreicher Johannes12, Redl Heinz12ORCID, Slezak Paul12
Affiliation:
1. Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, 1210 Vienna, Austria 2. Austrian Cluster for Tissue Regeneration, 1200 Vienna, Austria 3. Department of Physics, Utah Valley University, Orem, UT 84058, USA 4. University Clinic of Dentistry, Medical University of Vienna, 1090 Vienna, Austria 5. SCARLETRED Holding GmbH, 1030 Vienna, Austria
Abstract
Photobiomodulation, showing positive effects on wound healing processes, has been performed mainly with lasers in the red/infrared spectrum. Light of shorter wavelengths can significantly influence biological systems. This study aimed to evaluate and compare the therapeutic effects of pulsed LED light of different wavelengths on wound healing in a diabetic (db/db) mouse excision wound model. LED therapy by Repuls was applied at either 470 nm (blue), 540 nm (green) or 635 nm (red), at 40 mW/cm2 each. Wound size and wound perfusion were assessed and correlated to wound temperature and light absorption in the tissue. Red and trend-wise green light positively stimulated wound healing, while blue light was ineffective. Light absorption was wavelength-dependent and was associated with significantly increased wound perfusion as measured by laser Doppler imaging. Shorter wavelengths ranging from green to blue significantly increased wound surface temperature, while red light, which penetrates deeper into tissue, led to a significant increase in core body temperature. In summary, wound treatment with pulsed red or green light resulted in improved wound healing in diabetic mice. Since impeded wound healing in diabetic patients poses an ever-increasing socio-economic problem, LED therapy may be an effective, easily applied and cost-efficient supportive treatment for diabetic wound therapy.
Funder
Austrian Research Promotion Agency
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference40 articles.
1. Singh, G.M., Danaei, G., Farzadfar, F., Stevens, G.A., Woodward, M., Wormser, D., Kaptoge, S., Whitlock, G., Qiao, Q., and Lewington, S. (2013). The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis. PLoS ONE, 8. 2. Trends in Diabetes: Sounding the Alarm;Krug;Lancet,2016 3. Factors Affecting Wound Healing;Guo;J. Dent. Res.,2010 4. Wound Repair: Role of Immune-Epithelial Interactions;Leoni;Mucosal Immunol.,2015 5. Current Concepts for the Evaluation and Management of Diabetic Foot Ulcers;Mavrogenis;EFORT Open Rev.,2018
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Photobiomodulation Literature Watch March 2023;Photobiomodulation, Photomedicine, and Laser Surgery;2023-08-01
|
|