Fatty Liver Disease in Patients with Prediabetes and Overweight or Obesity

Author:

Arias-Fernández María123ORCID,Fresneda Sergio123ORCID,Abbate Manuela1234ORCID,Torres-Carballo Marina125,Huguet-Torres Aina12,Sánchez-Rodríguez Cristian26ORCID,Bennasar-Veny Miquel1237ORCID,Yañez Aina M.123ORCID,Busquets-Cortés Carla24ORCID

Affiliation:

1. Department of Nursing and Physiotherapy, University of Balearic Islands, 07122 Palma, Spain

2. Research Group on Global Health, University of Balearic Islands, 07122 Palma, Spain

3. Research Group on Global Health and Lifestyle, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain

4. ADEMA-SALUD Group of IUNICS, University of Balearic Islands, 07009 Palma, Spain

5. Primary Care Research Unit of Mallorca, Public Health Service of the Balearic Islands (Ibsalut), 07003 Palma, Spain

6. Sant Joan de Déu Hospital, 07007 Palma, Spain

7. CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a global health problem associated with liver morbimortality, obesity, and type 2 diabetes mellitus. This study aimed to analyze the prevalence of NAFLD (defined as a fatty liver index [FLI] ≥ 60) and its association with other cardiovascular risk (CVR) factors in patients with prediabetes and overweight/obesity. The present cross-sectional analysis uses baseline data from an ongoing randomized clinical trial. Sociodemographic and anthropometric characteristics, CVR (assessed by the REGICOR-Framingham risk equation), metabolic syndrome (MetS), and FLI-defined NAFLD (cut-off value of ≥60) were assessed. The prevalence of FLI-defined NAFLD was 78% overall. Men exhibited a worse cardiometabolic profile as compared to women, specifically, with higher values of systolic blood pressure (137.02 ± 13.48 vs. 131.22 ± 14.77 mmHg), diastolic blood pressure (85.33 ± 9.27 vs. 82.3 ± 9.12 mmHg), aspartate aminotransferase (AST) (27.23 ± 12.15 vs. 21.23 ± 10.05 IU/L), alanine aminotransferase (ALT) (34.03 ± 23.31 vs. 21.73 ± 10.80 IU/L), and higher CVR (5.58 ± 3.16 vs. 3.60 ± 1.68). FLI-defined NAFLD was associated with elevated AST, ALT, and the presence of MetS (73.7%) and CVR for the whole sample. People with prediabetes present a high burden of comorbidities related to CVR, despite clinical follow-up, and it is recommended to actively begin working with them to reduce their risks.

Funder

Ministry of Economy and Competitiveness, Carlos III Health Institute

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

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