Bridging the Gap from Enterotypes to Personalized Dietary Recommendations: A Metabolomics Perspective on Microbiome Research
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Published:2023-12-02
Issue:12
Volume:13
Page:1182
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ISSN:2218-1989
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Container-title:Metabolites
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language:en
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Short-container-title:Metabolites
Author:
Bartsch Madeline12, Hahn Andreas2ORCID, Berkemeyer Shoma1
Affiliation:
1. NutritionLab, Faculty of Agricultural Sciences and Landscape Architecture, Osnabrueck University of Applied Sciences, Am Kruempel 31, 49090 Osnabrueck, Germany 2. Institute of Food Science and Human Nutrition, Leibniz University Hannover, 30167 Hannover, Germany
Abstract
Advances in high-throughput DNA sequencing have propelled research into the human microbiome and its link to metabolic health. We explore microbiome analysis methods, specifically emphasizing metabolomics, how dietary choices impact the production of microbial metabolites, providing an overview of studies examining the connection between enterotypes and diet, and thus, improvement of personalized dietary recommendations. Acetate, propionate, and butyrate constitute more than 95% of the collective pool of short-chain fatty acids. Conflicting data on acetate’s effects may result from its dynamic signaling, which can vary depending on physiological conditions and metabolic phenotypes. Human studies suggest that propionate has overall anti-obesity effects due to its well-documented chemistry, cellular signaling mechanisms, and various clinical benefits. Butyrate, similar to propionate, has the ability to reduce obesity by stimulating the release of appetite-suppressing hormones and promoting the synthesis of leptin. Tryptophan affects systemic hormone secretion, with indole stimulating the release of GLP-1, which impacts insulin secretion, appetite suppression, and gastric emptying. Bile acids, synthesized from cholesterol in the liver and subsequently modified by gut bacteria, play an essential role in the digestion and absorption of dietary fats and fat-soluble vitamins, but they also interact directly with intestinal microbiota and their metabolites. One study using statistical methods identified primarily two groupings of enterotypes Bacteroides and Ruminococcus. The Prevotella-dominated enterotype, P-type, in humans correlates with vegetarians, high-fiber and carbohydrate-rich diets, and traditional diets. Conversely, individuals who consume diets rich in animal fats and proteins, typical in Western-style diets, often exhibit the Bacteroides-dominated, B-type, enterotype. The P-type showcases efficient hydrolytic enzymes for plant fiber degradation but has limited lipid and protein fermentation capacity. Conversely, the B-type features specialized enzymes tailored for the degradation of animal-derived carbohydrates and proteins, showcasing an enhanced saccharolytic and proteolytic potential. Generally, models excel at predictions but often struggle to fully elucidate why certain substances yield varied responses. These studies provide valuable insights into the potential for personalized dietary recommendations based on enterotypes.
Subject
Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism
Reference147 articles.
1. Stanislawski, M.A., Dabelea, D., Lange, L.A., Wagner, B.D., and Lozupone, C.A. (2019). Gut Microbiota Phenotypes of Obesity. NPJ Biofilms Microbiomes, 5. 2. Pinart, M., Dötsch, A., Schlicht, K., Laudes, M., Bouwman, J., Forslund, S.K., Pischon, T., and Nimptsch, K. (2021). Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis. Nutrients, 14. 3. Role of the Gut Microbiota in Type 2 Diabetes and Related Diseases;Yang;Metabolism,2021 4. Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications;Zhang;Mediat. Inflamm.,2021 5. The Gut Microbiota and Its Interactions with Cardiovascular Disease;Xu;Microb. Biotechnol.,2020
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