Exercise-Induced N-Lactoylphenylalanine Predicts Adipose Tissue Loss during Endurance Training in Overweight and Obese Humans

Author:

Hoene Miriam1ORCID,Zhao Xinjie2,Machann Jürgen345,Birkenfeld Andreas346,Heni Martin1347ORCID,Peter Andreas134,Niess Andreas89,Moller Anja346,Lehmann Rainer134ORCID,Xu Guowang2ORCID,Weigert Cora134ORCID

Affiliation:

1. Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, 72076 Tübingen, Germany

2. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

3. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the University of Tübingen, 72076 Tübingen, Germany

4. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany

5. Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, 72076 Tübingen, Germany

6. Department of Internal Medicine IV, University Hospital Tübingen, 72076 Tübingen, Germany

7. Division of Endocrinology and Diabetology, Department of Internal Medicine 1, University Hospital Ulm, 89081 Ulm, Germany

8. Department of Sports Medicine, University Hospital Tübingen, 72076 Tübingen, Germany

9. Interfaculty Research Institute for Sports and Physical Activity, University of Tübingen, 72076 Tübingen, Germany

Abstract

Physical exercise is a powerful measure to prevent cardiometabolic diseases. However, the individual response to lifestyle interventions is variable and cannot, to date, be predicted. N-Lactoylphenylalanine (Lac-Phe) produced during exercise has recently been shown to mediate weight loss in obese mice. Lac-Phe could also contribute to, and potentially explain differences in, the effectiveness of exercise interventions in humans. Sedentary overweight and obese subjects completed an 8-week supervised endurance exercise intervention (n = 22). Before and after the intervention, plasma levels of Lac-Phe were determined by UHPLC-MS in the resting state and immediately after an acute bout of endurance exercise. Adipose tissue volume was quantified using MRI. Acute exercise caused a pronounced increase in Lac-Phe, both before and after the intervention. Higher levels of Lac-Phe after acute exercise were associated with a greater reduction in abdominal subcutaneous and, to a lower degree, visceral adipose tissue during the intervention. Lac-Phe produced during physical activity could contribute to weight loss by acting as a signaling molecule that regulates food intake, as previously shown in mice. Quantification of Lac-Phe during an exercise test could be employed as a tool to predict and potentially improve the individual response to exercise-based lifestyle interventions in overweight humans and those with obesity.

Funder

Sino-German Center for Research Promotion

National Natural Science Foundation of China

German Federal Ministry of Education and Research

German Diabetes Association

University of Tübingen

Open Access Publishing Fund of the University of Tübingen

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

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