Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Author:

Liang Xin1,Li Xue1ORCID,Jin Yu1,Wang Yi1ORCID,Wei Changling2,Zhu Zhicheng1

Affiliation:

1. School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China

2. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA

Abstract

This study aimed to investigate the changes in intestinal homeostasis and metabolism in mice after methamphetamine (MA) administration and exercise intervention. In this study, male C57BL/B6J mice were selected to establish a model of methamphetamine-induced addiction, and the gut microbiota composition, short-chain fatty acids (SCFAs), and amino acid levels were assessed by 16S rRNA, liquid chromatography–tandem mass spectrometry, and gas chromatography–tandem mass spectrometry, respectively. The results showed that 23 dominant microbiota, 12 amino acids, and 1 SCFA were remarkably higher and 9 amino acids and 6 SCFAs were remarkably lower in the exercise model group than in the control group. Among the top 10 markers with opposite trends between the exercise intervention group and model group, the differential microbiomes included Oscillibacter, Alloprevotella, Colidextribacter, Faecalibaculum, Uncultured, Muribaculaceae, and Negativibacillus; amino acids included proline; and SCFAs included isovaleric acid and pentanoic acid. Proline was negatively correlated with Negativibacillus and positively correlated with pentanoic acid. The results suggested that moderate-intensity aerobic exercise may modulate changes in the composition of the gut microbiota and the levels of amino acids and SCFAs induced by MA administration.

Funder

Sichuan Drug Addiction Treatment Administration

Humanities and Social Sciences Project of the Ministry of Education

Sichuan Key Laboratory of Sports Medicin

Sichuan drug rehabilitation administration

Ziyang, Meishan, and Deyang drug-relief reformatories in Sichuan Province

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

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