Affiliation:
1. Biochemistry Research Laboratory, Omsk State Pedagogical University, 14 Tukhachevsky Str., 644043 Omsk, Russia
2. Clinical Oncology Dispensary, 9/1 Zavertyayeva Str., 644013 Omsk, Russia
3. Department of Oncology, Omsk State Medical University, 12 Lenina Str., 644099 Omsk, Russia
Abstract
This review analyzed 21 scientific papers on the determination of amino acids in various types of cancer in saliva. Most of the studies are on oral cancer (8/21), breast cancer (4/21), gastric cancer (3/21), lung cancer (2/21), glioblastoma (2/21) and one study on colorectal, pancreatic, thyroid and liver cancer. The amino acids alanine, valine, phenylalanine, leucine and isoleucine play a leading role in the diagnosis of cancer via the saliva. In an independent version, amino acids are rarely used; the authors combine either amino acids with each other or with other metabolites, which makes it possible to obtain high values of sensitivity and specificity. Nevertheless, a logical and complete substantiation of the changes in saliva occurring in cancer, including changes in salivary amino acid levels, has not yet been formed, which makes it important to continue research in this direction.
Funder
Russian Science Foundation
Subject
Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism
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