Nationwide COVID-19-EII Study: Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry
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Published:2022-01-14
Issue:2
Volume:11
Page:421
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ISSN:2077-0383
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Container-title:Journal of Clinical Medicine
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language:en
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Short-container-title:JCM
Author:
Zabana YamileORCID, Marín-Jiménez Ignacio, Rodríguez-Lago IagoORCID, Vera Isabel, Martín-Arranz María Dolores, Guerra IvánORCID, Gisbert Javier P.ORCID, Mesonero FranciscoORCID, Benítez OlgaORCID, Taxonera CarlosORCID, Ponferrada-Díaz Ángel, Piqueras Marta, Lucendo Alfredo J.ORCID, Caballol Berta, Mañosa Míriam, Martínez-Montiel Pilar, Bosca-Watts MaiaORCID, Gordillo Jordi, Bujanda Luis, Manceñido NoemíORCID, Martínez-Pérez Teresa, López Alicia, Rodríguez-Gutiérrez Cristina, García-López SantiagoORCID, Vega Pablo, Rivero MontserratORCID, Melcarne LuigiORCID, Calvo MariaORCID, Iborra MarisaORCID, Barreiro de-Acosta ManuelORCID, Sicilia Beatriz, Barrio JesúsORCID, Pérez José Lázaro, Busquets DavidORCID, Pérez-Martínez IsabelORCID, Navarro-Llavat MercèORCID, Hernández VicentORCID, Argüelles-Arias FedericoORCID, Ramírez Esteso Fernando, Meijide Susana, Ramos LauraORCID, Gomollón FernandoORCID, Muñoz Fernando, Suris Gerard, de Zarate Jone Ortiz, Huguet José MaríaORCID, Llaó Jordina, García-Sepulcre Mariana Fe, Sierra MónicaORCID, Durà Miguel, Estrecha Sandra, Fuentes Coronel AnaORCID, Hinojosa Esther, Olivan Lorenzo, Iglesias Eva, Gutiérrez Ana, Varela Pilar, Rull Núria, Gilabert Pau, Hernández-Camba AlejandroORCID, Brotons AliciaORCID, Ginard Daniel, Sesé Eva, Carpio Daniel, Aceituno MontserratORCID, Cabriada José LuisORCID, González-Lama YagoORCID, Jiménez Laura, Chaparro MaríaORCID, López-San Román Antonio, Alba Cristina, Plaza-Santos RocíoORCID, Mena Raquel, Tamarit-Sebastián SonsolesORCID, Ricart Elena, Calafat Margalida, Olivares Sonsoles, Navarro PabloORCID, Bertoletti Federico, Alonso-Galán Horacio, Pajares Ramón, Olcina PabloORCID, Manzano Pamela, Domènech EugeniORCID, Esteve Maria,
Abstract
We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA registry (53,682 from 73 centres) between March–July 2020 followed-up for 12 months. Results were compared with data of the general population (National Centre of Epidemiology and Catalonia). A total of 482 patients with COVID-19 were identified. Twenty-eight percent were infected in the work environment, and 48% were infected by intrafamilial transmission, despite having good adherence to lockdown. Thirty-five percent required hospitalization, 7.9% had severe COVID-19 and 3.7% died. Similar data were reported in the general population (hospitalisation 19.5%, ICU 2.1% and mortality 4.6%). Factors related to death and severe COVID-19 were being aged ≥ 60 years (OR 7.1, 95% CI: 1.8–27 and 4.5, 95% CI: 1.3–15.9), while having ≥2 comorbidities increased mortality (OR 3.9, 95% CI: 1.3–11.6). None of the drugs for IBD were related to severe COVID-19. Immunosuppression was definitively stopped in 1% of patients at 12 months. The prognosis of COVID-19 in IBD, even in immunosuppressed patients, is similar to that in the general population. Thus, there is no need for more strict protection measures in IBD.
Funder
Instituto de Salud Carlos III Fondo Europeo de Desarrollo Regional
Cited by
9 articles.
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