The Effectiveness of Semi-Supervised Learning Techniques in Identifying Calcifications in X-ray Mammography and the Impact of Different Classification Probabilities

Author:

Sakaida Miu1,Yoshimura Takaaki2345ORCID,Tang Minghui56,Ichikawa Shota78ORCID,Sugimori Hiroyuki459ORCID,Hirata Kenji456ORCID,Kudo Kohsuke456ORCID

Affiliation:

1. Graduate School of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan

2. Department of Health Sciences and Technology, Faculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan

3. Department of Medical Physics, Hokkaido University Hospital, Sapporo 060-8648, Japan

4. Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo 060-8648, Japan

5. Clinical AI Human Resources Development Program, Faculty of Medicine, Hokkaido University, Sapporo 060-8648, Japan

6. Department of Diagnostic Imaging, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan

7. Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Niigata 951-8518, Japan

8. Institute for Research Administration, Niigata University, Niigata 950-2181, Japan

9. Department of Biomedical Science and Engineering, Faculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan

Abstract

Identifying calcifications in mammograms is crucial for early breast cancer detection, and semi-supervised learning, which utilizes a small dataset for supervised learning combined with deep learning, is anticipated to be an effective approach for automating this identification process. This study explored the impact of semi-supervised learning on identifying mammographic calcifications by including 712 mammographic images from 252 patients in public datasets. Initially, 212 mammogram images were segmented into patches and classified visually for calcification presence. A subset of these patches, derived from 169 mammogram images, was used to train a ResNet50-based classifier. The classifier was evaluated using patches generated from 43 mammograms as a test data set. Additionally, 500 more mammogram images were processed into patches and analyzed using the trained ResNet50 model, with semi-supervised learning applied to patches exceeding certain classification probabilities. This process aimed to enhance the classifier’s accuracy and achieve improvements over the initial model. The findings indicated that semi-supervised learning significantly benefits the accuracy of calcification detection in mammography, underscoring its utility in enhancing diagnostic methodologies.

Publisher

MDPI AG

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