Detection of SARS-CoV-2 RNA in a Zoo-Kept Red Fox (Vulpes vulpes)-Reference-Cited by-同舟云学术

Detection of SARS-CoV-2 RNA in a Zoo-Kept Red Fox (Vulpes vulpes)

Published:2024-03-28 Issue:4 Volume:16 Page:521
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Chan Tatjana¹^ORCID,Ginders Julia¹,Kuhlmeier Evelyn¹,Meli Marina L.¹^ORCID,Bönzli Eva¹,Meili Theres¹,Hüttl Julia¹^ORCID,Hatt Jean-Michel²,Hindenlang Clerc Karin³,Kipar Anja⁴^ORCID,Wyss Fabia⁵,Wenker Christian⁵,Ryser-Degiorgis Marie-Pierre⁶,Valenzuela Agüí Cecilia⁷⁸^ORCID,Urban Christian⁹,Beisel Christian⁷,Stadler Tanja⁷⁸^ORCID,Hofmann-Lehmann Regina¹^ORCID

Affiliation:

1. Clinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland

2. Clinic for Zoo Animals, Exotic Pets and Wildlife, Department of Small Animals, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland

3. Foundation Wildnispark Zurich, Alte Sihltalstrasse 38, 8135 Sihlwald, Switzerland

4. Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, 8057 Zurich, Switzerland

5. Zoologischer Garten Basel AG, Binningerstrasse 40, 4054 Basel, Switzerland

6. Institute for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland

7. Department of Biosystems Science and Engineering, ETH Zurich, Schanzenstrasse 44, Postfach, 4009 Basel, Switzerland

8. SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland

9. Functional Genomics Center, ETH Zurich and University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland

Abstract

Many different animal species are susceptible to SARS-CoV-2, including a few Canidae (domestic dog and raccoon dog). So far, only experimental evidence is available concerning SARS-CoV-2 infections in red foxes (Vulpes vulpes). This is the first report of SARS-CoV-2 RNA detection in a sample from a red fox. The RT-qPCR-positive fox was zoo-kept together with another fox and two bears in the Swiss Canton of Zurich. Combined material from a conjunctival and nasal swab collected for canine distemper virus diagnostics tested positive for SARS-CoV-2 RNA with Ct values of 36.9 (E gene assay) and 35.7 (RdRp gene assay). The sample was analysed for SARS-CoV-2 within a research project testing residual routine diagnostic samples from different animal species submitted between spring 2020 and December 2022 to improve knowledge on SARS-CoV-2 infections within different animal species and investigate their potential role in a One Health context. Within this project, 246 samples from 153 different animals from Swiss zoos and other wild animal species all tested SARS-CoV-2 RT-qPCR and/or serologically negative so far, except for the reported fox. The source of SARS-CoV-2 in the fox is unknown. The fox disappeared within the naturally structured enclosure, and the cadaver was not found. No further control measures were undertaken.

Funder

University of Zurich (UZH

Publisher

MDPI AG

Link

https://www.mdpi.com/1999-4915/16/4/521/pdf

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