Affiliation:
1. Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, Piazza Rinascimento 6, 61029 Urbino, PU, Italy
2. Department of Industrial Chemistry “T. Montanari”, University of Bologna, Viale Risorgimento 4, 40136 Bologna, BO, Italy
Abstract
The synthesis of dibenzyl-(1S*,2S*)-2,3-dihydro-1H-indene-1,2-dicarboxylate has been realized through a diastereospecific bis-alkoxycarbonylation reaction, which starts from the cheap and easily available 1H-indene, benzyl alcohol, and carbon monoxide. The catalyst is formed in situ by mixing Pd(TFA)2, the ligand N2,N3-bis(2,6-dimethylphenyl)butane-2,3-diimine, p-benzoquinone is used as an oxidant, and benzyl alcohol acts both as a nucleophile and as the main solvent.
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry