Author:
Xu Ji,He Yuan,Sun Yanan,Zhang Xiuming,Yi Yunfeng,Shi Wei,Ge Dongtao
Abstract
Conductive polypyrrole (PPy) has excellent biocompatibility and structural stability. It is an ideal electroactive biomaterial that can apply exogenous electrical stimulation to promote osteoblast differentiation. However, PPy is a kind of bio-inert material, which does not have osteoinductive capacity. Therefore, we have introduced a kind of bioactive material, hydroxyapatite (HA), to construct PPy/HA composite to enhance bioactivity and osteoinduction. In addition, micron-topological morphology of scattered grid pattern has been designed and introduced to the PPy/HA coatings, which can further enhance the regulation ability of the coatings to the adhesion, proliferation and differentiation of MC3T3-E1 cells. In vitro simulated body fluids (SBFs) immersion test results have demonstrated that the fabricated micropatterned PPy/HA composite coatings perform bioactivity well and can promote the mineral deposition of HA on the surface. Moreover, it can also benefit the proliferation and osteognetic differentiation of MC3T3-E1 cells, when accompanied by external electrical stimulation (ES). In this study, we have successfully constructed electroactive and bioactive coatings, the method of which can potentially be applied to the surface functional modification of traditional bone repair metals.
Funder
National Natural Science Foundation of China
Program for New Century Excellent Talents in University, the Natural Science Foundation of Fujian Province
Subject
Materials Chemistry,Surfaces, Coatings and Films,Surfaces and Interfaces
Cited by
3 articles.
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