Investigation of Polyelectrolyte Multilayers Deposited on Biodegradable Corona-Charged Substrates Used as Drug Delivery Systems

Abstract

Polyelectrolyte multilayers (PEMs) deposited on porous composite polylactic acid/poly(ε-caprolactone) (PDLA/PEC) substrates were studied. The substrates were previously charged in a corona discharge. Time dependences of the normalized surface potential for positively and negatively charged electrets were investigated. The morphology of the obtained porous substrates was examined by means of scanning electron microscopy (SEM). The chitosan and the casein polyelectrolytes were deposited on the substrates using the layer-by-layer (LbL) technique. The drug loading efficiency and the release kinetics were determined spectrophotometrically.