Author:
Thompson Michael D.,DeBosch Brian J.
Abstract
Developmental programming of chronic diseases by perinatal exposures/events is the basic tenet of the developmental origins hypothesis of adult disease (DOHaD). With consumption of fructose becoming more common in the diet, the effect of fructose exposure during pregnancy and lactation is of increasing relevance. Human studies have identified a clear effect of fructose consumption on maternal health, but little is known of the direct or indirect effects on offspring. Animal models have been utilized to evaluate this concept and an association between maternal fructose and offspring chronic disease, including hypertension and metabolic syndrome. This review will address the mechanisms of developmental programming by maternal fructose and potential options for intervention.
Funder
National Institutes of Health
American Gastroenterological Association
Doris Duke Charitable Foundation
Gilead Sciences
American Federation for Aging Research
Subject
Food Science,Nutrition and Dietetics
Cited by
9 articles.
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