Recent Advances of Composite Nanomaterials for Antibiofilm Application

Author:

Qi Ruilian1ORCID,Cui Yuanyuan1,Liu Jian2ORCID,Wang Xiaoyu3ORCID,Yuan Huanxiang1ORCID

Affiliation:

1. Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China

2. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100090, China

3. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China

Abstract

A biofilm is a microbial community formed by bacteria that adsorb on the surface of tissues or materials and is wrapped in extracellular polymeric substances (EPS) such as polysaccharides, proteins and nucleic acids. As a protective barrier, the EPS can not only prevent the penetration of antibiotics and other antibacterial agents into the biofilm, but also protect the bacteria in the biofilm from the attacks of the human immune system, making it difficult to eradicate biofilm-related infections and posing a serious threat to public health. Therefore, there is an urgent need to develop new and efficient antibiofilm drugs. Although natural enzymes (lysozyme, peroxidase, etc.) and antimicrobial peptides have excellent bactericidal activity, their low stability in the physiological environment and poor permeability in biofilms limit their application in antibiofilms. With the development of materials science, more and more nanomaterials are being designed to be utilized for antimicrobial and antibiofilm applications. Nanomaterials have great application prospects in antibiofilm because of their good biocompati-bility, unique physical and chemical properties, adjustable nanostructure, high permeability and non-proneness to induce bacterial resistance. In this review, with the application of composite nanomaterials in antibiofilms as the theme, we summarize the research progress of three types of composite nanomaterials, including organic composite materials, inorganic materials and organic–inorganic hybrid materials, used as antibiofilms with non-phototherapy and phototherapy modes of action. At the same time, the challenges and development directions of these composite nanomaterials in antibiofilm therapy are also discussed. It is expected we will provide new ideas for the design of safe and efficient antibiofilm materials.

Funder

Beijing Municipal Education Commission project

project of cultivation for young top-notch talents of Beijing Municipal Institutions

Publisher

MDPI AG

Subject

General Materials Science,General Chemical Engineering

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