CAR-T Cells for the Treatment of Lung Cancer

Author:

Chocarro LuisaORCID,Arasanz HugoORCID,Fernández-Rubio Leticia,Blanco EsterORCID,Echaide Miriam,Bocanegra AnaORCID,Teijeira Lucía,Garnica Maider,Morilla Idoia,Martínez-Aguillo Maite,Piñeiro-Hermida SergioORCID,Ramos PabloORCID,Lasarte Juan JoséORCID,Vera RuthORCID,Kochan Grazyna,Escors David

Abstract

Adoptive cell therapy with genetically modified T lymphocytes that express chimeric antigen receptors (CAR-T) is one of the most promising advanced therapies for the treatment of cancer, with unprecedented outcomes in hematological malignancies. However, the efficacy of CAR-T cells in solid tumors is still very unsatisfactory, because of the strong immunosuppressive tumor microenvironment that hinders immune responses. The development of next-generation personalized CAR-T cells against solid tumors is a clinical necessity. The identification of therapeutic targets for new CAR-T therapies to increase the efficacy, survival, persistence, and safety in solid tumors remains a critical frontier in cancer immunotherapy. Here, we summarize basic, translational, and clinical results of CAR-T cell immunotherapies in lung cancer, from their molecular engineering and mechanistic studies to preclinical and clinical development.

Funder

Asociación Española Contra el Cáncer

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

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