A pH-Responsive Polycaprolactone–Copper Peroxide Composite Coating Fabricated via Suspension Flame Spraying for Antimicrobial Applications-Reference-Cited by-同舟云学术

A pH-Responsive Polycaprolactone–Copper Peroxide Composite Coating Fabricated via Suspension Flame Spraying for Antimicrobial Applications

Published:2024-06-01 Issue:11 Volume:17 Page:2666
ISSN:1996-1944
Container-title:Materials
language:en
Short-container-title:Materials

Author:

Cui Tingting¹²,Zhou Daofeng¹²,Zhang Yu¹²,Kong Decong¹²,Wang Zhijuan¹²,Han Zhuoyue¹²,Song Meiqi¹²,Aimaier Xierzhati¹²,Dan Yanxin³,Zhang Botao¹²⁴,Li Hua¹²⁴

Affiliation:

1. Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou 325035, China

2. Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China

3. Graduate School of Engineering, Tohoku University, Sendai 980-8577, Japan

4. Zhejiang-Japan Joint Laboratory for Antibacterial and Antifouling Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo 315201, China

Abstract

In this study, a pH-responsive polycaprolactone (PCL)–copper peroxide (CuO2) composite antibacterial coating was developed by suspension flame spraying. The successful synthesis of CuO2 nanoparticles and fabrication of the PCL-CuO2 composite coatings were confirmed by microstructural and chemical analysis. The composite coatings were structurally homogeneous, with the chemical properties of PCL well maintained. The acidic environment was found to effectively accelerate the dissociation of CuO2, allowing the simultaneous release of Cu2+ and H2O2. Antimicrobial tests clearly revealed the enhanced antibacterial properties of the PCL-CuO2 composite coating against both Escherichia coli and Staphylococcus aureus under acidic conditions, with a bactericidal effect of over 99.99%. This study presents a promising approach for constructing pH-responsive antimicrobial coatings for biomedical applications.

Funder

Zhejiang Basic Public Welfare Research Program of China

National Natural Science Foundation of China

Key Research and Development Program of Ningbo

K.C. Wong Education Foundation

Publisher

MDPI AG

Link

https://www.mdpi.com/1996-1944/17/11/2666/pdf

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