The Role of Adipokines in the Pathogenesis of Psoriasis

Author:

Kiełbowski Kajetan1ORCID,Bakinowska Estera1,Ostrowski Piotr1ORCID,Pala Bartłomiej1,Gromowska Ewa1,Gurazda Klaudia1,Dec Paweł2ORCID,Modrzejewski Andrzej3,Pawlik Andrzej1ORCID

Affiliation:

1. Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland

2. Plastic and Reconstructive Surgery Department, 109 Military Hospital, 71-422 Szczecin, Poland

3. Department of Surgery, Pomeranian Medical University, 71-422 Szczecin, Poland

Abstract

Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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