Affiliation:
1. College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China
2. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China
Abstract
Inflammatory dysfunction and angiogenesis inhibition are two main factors leading to the delayed healing of diabetic wounds. Hydrogels with anti-inflammatory and angiogenesis-promoting effects have been considered as promising wound care materials. Herein, a salvianolic acid B (SAB)-loaded hyaluronic acid (HA) self-healing hydrogel (HA/SAB) with anti-inflammatory and pro-angiogenesis capacities for diabetic wound healing is reported. The HA hydrogel was prepared via the covalent cross-linking of aldehyde groups in oxidized HA (OHA) and hydrazide groups in adipic dihydrazide (ADH)-modified HA (HA-ADH) with the formation of reversible acylhydrazone bonds. The obtained HA hydrogel exhibited multiple favorable properties such as porous structures, excellent self-healing properties, a sustainable release capacity of SAB, as well as excellent cytocompatibility. In addition, the effects of the SAB-loaded HA self-healing hydrogel were investigated via a full-thickness skin defect model using diabetic rats. The HA/SAB hydrogel showed enhanced skin regeneration effects with accelerated wound closure, shorter remaining dermal space length, thicker granulation tissue formation, and more collagen deposition. Furthermore, reduced inflammatory response and enhanced vascularization were found with HA/SAB2.5 hydrogel-treated wounds, indicating that the hydrogel promotes diabetic wound healing through the promotion of anti-inflammation and angiogenesis. Our results suggest that the fabricated SAB-loaded HA self-healing hydrogel is promising as a wound dressing for the treatment of diabetic wounds.
Funder
Zhejiang Provincial Natural Science Foundation of China
National Natural Science Foundation of China
Research Project on Chinese Medicine Health Services
Research Project of Zhejiang Chinese Medical University
College level scientific research cultivation project of Zhejiang Chinese Medical University
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference46 articles.
1. Pathophysiology of diabetes: An overview;Banday;Avicenna J. Med.,2020
2. Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers;McDermott;Diabetes Care,2023
3. Rehak, L., Giurato, L., Meloni, M., Panunzi, A., Manti, G.M., and Uccioli, L. (2022). The Immune-Centric Revolution in the Diabetic Foot: Monocytes and Lymphocytes Role in Wound Healing and Tissue Regeneration—A Narrative Review. J. Clin. Med., 11.
4. Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing;Kharaziha;Adv. Mater.,2021
5. Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9;Nguyen;Wound Repair Regen.,2020
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献