Affiliation:
1. Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903, USA
Abstract
Particulate matter in the air exacerbates airway inflammation (AI) in asthma; moreover, prenatal exposure to concentrated urban air particles (CAPs) and diesel exhaust particles (DEPs) predisposes the offspring to asthma and worsens the resolution of AI in response to allergens. We previously tested the hypothesis that such exposure impairs the pathways of specialized proresolving mediators that are critical for resolution and found declined Lipoxin A4 (LxA4) and Resolvin E2 (RvE2) levels in the “at-risk” pups of exposed mothers. Here, we hypothesized that supplementation with synthetic LxA4 or RvE2 via the airway can ameliorate AI after allergen exposure, which has not been tested in models with environmental toxicant triggers. BALB/c newborns with an asthma predisposition resultant from prenatal exposure to CAPs and DEPs were treated once daily for 3 days with 750 ng/mouse of LxA4 or 300 ng/mouse of RvE2 through intranasal instillation, and they were tested with the intentionally low-dose ovalbumin protocol that elicits asthma in the offspring of particle-exposed mothers but not control mothers, mimicking the enigmatic maternal transmission of asthma seen in humans. LxA4 and RvE2 ameliorated the asthma phenotype and improved AI resolution, which was seen as declining airway eosinophilia, lung tissue infiltration, and proallergic cytokine levels.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference88 articles.
1. Air pollutants and early origins of respiratory diseases;Kim;Chronic Dis. Transl. Med.,2018
2. Effects of long-term exposure to traffic-related air pollution on respiratory and cardiovascular mortality in The Netherlands: The NLCS-AIR study;Brunekreef;Res. Rep. Health Eff. Inst.,2009
3. Fine particulate pollution and asthma exacerbations;Bouazza;Arch. Dis. Child.,2018
4. Exposition à la pollution atmosphérique de proximité liée au trafic: Quelles méthodes pour quels risques sanitaires? [Health risk assessment of traffic-related air pollution near busy roads];Host;Rev. Epidemiol. Sante Publique,2012
5. The contribution of particulate matter to respiratory allergy;Sompornrattanaphan;Asian Pac. J. Allergy Immunol.,2020
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献