Carbon Nanomaterials: Emerging Roles in Immuno-Oncology

Author:

Patrick Bbumba123ORCID,Akhtar Tahira1234,Kousar Rubina1235,Huang Chih-Ching6ORCID,Li Xing-Guo123

Affiliation:

1. Graduate Institute of Biomedical Sciences, China Medical University, Taichung 406040, Taiwan

2. Research Center for Cancer Biology, China Medical University, Taichung 406040, Taiwan

3. Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung 406040, Taiwan

4. Institute of Translational Medicine and New Drug Development, China Medical University, Taichung 406040, Taiwan

5. Department of Biological Science and Technology, China Medical University, Taichung 406040, Taiwan

6. Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan

Abstract

Cancer immunotherapy has made breakthrough progress in cancer treatment. However, only a subset of patients benefits from immunotherapy. Given their unique structure, composition, and interactions with the immune system, carbon nanomaterials have recently attracted tremendous interest in their roles as modulators of antitumor immunity. Here, we focused on the latest advances in the immunological effects of carbon nanomaterials. We also reviewed the current preclinical applications of these materials in cancer therapy. Finally, we discussed the challenges to be overcome before the full potential of carbon nanomaterials can be utilized in cancer therapies to ultimately improve patient outcomes.

Funder

Andrew McDonough B+ (Be Positive) Foundation’s Childhood Cancer Research Award

Children’s Cancer Research Fund’s Emerging Scientist Award

National Science and Technology Council

China Medical University

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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