Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis-Reference-Cited by-同舟云学术

Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis

Published:2024-03-08 Issue:3 Volume:16 Page:142
ISSN:2072-6651
Container-title:Toxins
language:en
Short-container-title:Toxins

Author:

Chang Estrada Jorge Eduardo¹,Guerrero Taissa Nunes¹,Reyes-Enríquez Daniel Fernando¹,Nardy Erica Santos¹,Guimarães Ferreira Roseane²,Ruiz Calderón Cristian José³^ORCID,Wellmann Irmgardt A.⁴⁵^ORCID,Monteiro Espíndola Kaio Murilo⁶,do Prado Alejandro Ferraz⁷^ORCID,Soares Andreimar Martins⁸⁹¹⁰,Fontes Marcos Roberto de Mattos¹⁰¹¹¹²^ORCID,Chagas Monteiro Marta²^ORCID,Zingali Russolina Benedeta¹^ORCID

Affiliation:

1. Instituto de Bioquímica Médica Leopoldo de Meis CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil

2. Postgraduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém 66075-110, PA, Brazil

3. Department of Biochemistry and Microbiology, Universidad del Valle de Guatemala, Guatemala City 01015, Guatemala

4. Postgraduate Program in Tropical Medicine, State University of Amazonas, Manaus 69005-010, AM, Brazil

5. Faculty of Medical Sciences, Universidad de San Carlos de Guatemala, Guatemala City 01015, Guatemala

6. Postgraduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Pará, Belém 66075-110, PA, Brazil

7. Laboratory of Pharmacology and Toxicology of Cardiovascular System, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil

8. Laboratory of Biotechnology and Education Applied to One Health (LABIOPROT), Oswaldo Cruz Foundation, FIOCRUZ, RONDÔNIA, Federal University of Rondônia, UNIR, Porto Velho 76812-245, RO, Brazil

9. Sao Lucas University Center, SÃO LUCAS PVH, Porto Velho 76804-414, RO, Brazil

10. Western Amazon Research and Knowledge Network of Excellence (RED-CONEXAO), Basic and Applied Toxinology Research Network (RED-TOX), the National Institute of Science and Technology of Epidemiology of the Western Amazon (INCT EpiAmO), Porto Velho 76812-245, Ro, Brazil

11. Institute for Advanced Studies of the Sea (IEAMar), Universidade Estadual Paulista (UNESP), São Vicente 11350-011, SP, Brazil

12. Department of Biophysics and Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu 18618-970, SP, Brazil

Abstract

Central America is home to one of the most abundant herpetofauna in the Americas, occupying only 7% of the continent’s total area. Vipers and lizards are among the most relevant venomous animals in medical practice due to the consequences of envenomation from the bite of these animals. A great diversity of biomolecules with immense therapeutic and biotechnological value is contained in their venom. This paper describes the prominent leading representatives of the family Viperidae, emphasizing their morphology, distribution, habitat, feeding, and venom composition, as well as the biotechnological application of some isolated components from the venom of the animals from these families, focusing on molecules with potential anti-thrombotic action. We present the leading protein families that interfere with blood clotting, platelet activity, or the endothelium pro-thrombotic profile. In conclusion, Central America is an endemic region of venomous animals that can provide many molecules for biotechnological applications.

Funder

FAPERJ

CNPq

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6651/16/3/142/pdf

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