Brodalumab for the Treatment of Moderate-to-Severe Psoriasis: An Expert Delphi Consensus Statement-Reference-Cited by-同舟云学术

Brodalumab for the Treatment of Moderate-to-Severe Psoriasis: An Expert Delphi Consensus Statement

Published:2023-05-18 Issue:10 Volume:12 Page:3545
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Fargnoli Maria Concetta¹²^ORCID,Bardazzi Federico³,Bianchi Luca⁴⁵,Dapavo Paolo⁶,Fabbrocini Gabriella⁷,Gisondi Paolo⁸^ORCID,Micali Giuseppe⁹,Offidani Anna Maria¹⁰,Pellacani Giovanni¹¹,Skroza Nevena¹²^ORCID,Angileri Rosa Giuseppa¹³,Burlando Martina¹⁴^ORCID,Campanati Anna¹⁵^ORCID,Carrera Carlo Giovanni¹⁶,Chiricozzi Andrea¹⁷¹⁸^ORCID,Conti Andrea¹⁹,Simone Clara De¹⁷¹⁸^ORCID,Di Lernia Vito²⁰,Errichetti Enzo²¹,Galluzzo Marco⁴⁵^ORCID,Guarneri Claudio²²^ORCID,Lasagni Claudia²³,Lembo Serena²⁴,Loconsole Francesco²⁵²⁶,Megna Matteo⁷^ORCID,Musumeci Maria Letizia⁹,Prignano Francesca²⁷^ORCID,Richetta Antonio Giovanni²⁸,Trovato Emanuele²⁹^ORCID,Venturini Marina³⁰,Peris Ketty¹⁷¹⁸,Pinton Piergiacomo Calzavara³⁰

Affiliation:

1. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy

2. Dermatology Unit, Ospedale San Salvatore, 67100 L’Aquila, Italy

3. Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola Malpighi, 40126 Bologna, Italy

4. Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy

5. Dermatology Unit, Azienda Ospedaliera Universitaria “Policlinico Tor Vergata”, 00133 Rome, Italy

6. Dermatology Clinic, Department of Medical Sciences, University of Turin, 10124 Turin, Italy

7. Section of Dermatology, Department of Clinical, Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy

8. Section of Dermatology and Venereology, Department of Medicine, University of Verona, 37129 Verona, Italy

9. Department of Dermatology, University of Catania, 95123 Catania, Italy

10. Department of Clinical and Molecular Sciences, Dermatology Unit, Polytechnic Marche University, 60121 Ancona, Italy

11. Dermatology Clinic, Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza Medical School, Sapienza University of Rome, 00185 Rome, Italy

12. Dermatology Unit “D. Innocenzi”, Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome-Polo Pontino, 04100 Latina, Italy

13. UOC Dermatologia, ARNAS Civico Di Palermo, 90127 Palermo, Italy

14. Clinica Dermatologica, DissaL, Ospedale Policlinico San Martino-IRCCS, 16132 Genova, Italy

15. Department of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, 60121 Ancona, Italy

16. Dermatology Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy

17. Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168 Rome, Italy

18. UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli–IRCCS, 00168 Rome, Italy

19. Dermatologic Unit, Department of Surgery, Infermi Hospital, AUSL Romagna, 47923 Rimini, Italy

20. Dermatology Unit, Arcispedale S. Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy

21. Institute of Dermatology, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), University of Udine, 33100 Udine, Italy

22. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98122 Messina, Italy

23. Clinica Dermatologica, Dipartimento delle Medicine Specialistiche AOU Policlinico di Modena, 41121 Modena, Italy

24. Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, Italy

25. Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70121 Bari, Italy

26. Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, 70124 Bari, Italy

27. Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy

28. Unit of Dermatology, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00185 Rome, Italy

29. Section of Dermatology, Department of Medical, Surgical and Neurological Science, S. Maria alle Scotte Hospital, University of Siena, 53100 Siena, Italy

30. Dermatology Department, University of Brescia, 25121 Brescia, Italy

Abstract

Brodalumab is a recombinant, fully human immunoglobulin IgG2 monoclonal antibody specifically targeted against interleukin-17RA that has been approved for the treatment of moderate-to-severe psoriasis in Europe. We developed a Delphi consensus document focused on brodalumab for the treatment of moderate-to-severe psoriasis. Based on published literature and their clinical experience a steering committee drafted 17 statements covering 7 domains specific to the treatment of moderate-to-severe psoriasis with brodalumab. A panel of 32 Italian dermatologists indicated their level of agreement using a 5-point Likert scale (from 1 = “strongly disagree” to 5 = “strongly agree”) using an online modified Delphi method. After the first round of voting (32 participants), positive consensus was reached for 15/17 (88.2%) of the proposed statements. Following a face-to-face virtual meeting, the steering committee decided that 5 statements would form “main principles” and 10 statements formed the final list. After a second round of voting, consensus was reached in 4/5 (80%) of the main principles and 8/10 (80%) for consensus statements. The final list of 5 main principles and 10 consensus statements identify key indications specific to the use of brodalumab in the treatment of moderate-to-severe psoriasis in Italy. These statements aid dermatologists in the management of patients with moderate-to-severe psoriasis.

Funder

Leo Pharma

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2077-0383/12/10/3545/pdf

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