Abstract
Three copper(I) dithiocarbamate–phosphine complexes of the general formula Cu(PPh3)2L were synthesized by metathesis reactions of the potassium salt of the dithiocarbamate ligand L and the precursor complex Cu(PPh3)2NO3 in an equimolar ratio. L represents N,N′-bis(2,6-dimethylphenyl)formamidine dithiocarbamate L1 in complex 1, N,N′-bis(2,6-disopropylphenyl) formamidine dithiocarbamate L2 in complex 2, and N,N′-dimesitylformamidine dithiocarbamate L3 in complex 3. The single-crystal X-ray structure revealed the coordination of the copper atom to two sulfur atoms of the dithiocarbamates, as well as two phosphorus atoms of the PPh3 units, which resulted in distorted tetrahedral geometries. The calculated τ4 (tau factor) values for 1, 2 and 3 were 0.82, 0.81 and 0.85, respectively, confirming the pseudo-tetrahedral geometry proposed. Complexes 1–3 showed remarkable luminescent properties in CH2Cl2 at room temperature. All three complexes showed moderate-to-low antibacterial potential against Gram-negative bacteria, while none of the complexes were active against Gram-positive bacteria. The DPPH assay studies showed that complex 2 had the lowest IC50 (4.99 × 10−3 mM),and had higher DPPH free radical scavenging ability than 1 and 3. The pharmacological estimations of 1–3 showed that all of the complexes showed minimal violation of Lipinski’s rule.
Funder
National Research Foundation
Cited by
3 articles.
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