Affiliation:
1. Faculty of Chemistry, National Research Tomsk State University, Tomsk 634050, Russia
Abstract
During the interaction of aqueous-ethanol or ethanol solutions AgNO3, H[AuCl4], and CuCl2, as well as aqueous suspensions of slightly soluble copper(II) salts Cu(C6H4NO2)2·H2O, Cu(C7H5O2)2∙3H2O, and CuC7H4O3∙H2O with the ethanol solution of clotrimazole at pH of ~(5.0–5.5), the [Ag(C22H17ClN2)2]NO3·2H2O, [Au(C22H17ClN2)Cl3], [Cu(C22H17ClN2)2Cl2]·5H2O, Cu(C22H17ClN2)4(C6H4NO2)2, Cu(C22H17ClN2)4(C7H5O2)2, and Cu(C22H17ClN2)3(C7H4O3)·2H2O compounds are synthesised. They are characterised by elemental, thermal, thermogravimetric, and IR spectroscopic methods of analysis. The [Ag(C22H17ClN2)2]NO3·2H2O complex was shown to have a higher antimycotic activity against Saccharomyces cerevisiae fungi than that of AgNO3 and C22H17ClN2. Cocrystals/salts of the composition C22H17ClN2·C6H5NO2, C22H17ClN2·C7H6O2, 2C22H17ClN2·C7H6O3, and 2C22H17ClN2·C19H19O6N7·H2O are obtained from aqueous and aqueous ethanol suspensions containing nicotinic, benzoic, salicylic, and folic acids and clotrimazole (pH is 4.5–6.0). These cocrystals and salts were studied usin thermogravimetric, IR-spectroscopic methods. Diffraction patterns of the powders were obtained. The influence of the difference in the pKa components on the ability to form cocrystals/salts was assessed.
Funder
Tomsk State University Development Program
Reference29 articles.
1. Antimicrobial Efficacy and Synergy of Metal Ions against Enterococcus faecium, Klebsiella pneumoniae and Acinetobacter baumannii in Planktonic and Biofilm Phenotypes;Vaidya;Sci. Rep.,2017
2. Mahendra, R., Avinash, P.I., and Serenella, M. (2018). Biomedical Applications of Metals, Springer International Publishing AG.
3. Synthesis, single crystal X-ray, spectroscopic characterization and biological activities of Mn2+, Co2+, Ni2+ and Fe3+ complexes;Hassoon;J. Mol. Struct.,2020
4. Synthesis, spectral, electrochemical, in-vitro antimicrobial and antioxidant activities of bisphenolic mannich base and 8-hydroxyquinoline based mixed ligands and their transition metal complexes;Indira;J. Mol. Struct.,2019
5. Sinuk, T.F. (2002). Standardization of Quantitative Testing of Individual and Combined Toxic Effects of Copper(II), Silver(I), Zinc(II), Nickel(II) and Clotrimazole Salts. [Ph.D. Thesis, Moscow Medical Academy].