Evaluation of Membrane Permeability of Copper-Based Drugs-Reference-Cited by-同舟云学术

Evaluation of Membrane Permeability of Copper-Based Drugs

Published:2023-04-23 Issue:5 Volume:11 Page:179
ISSN:2304-6740
Container-title:Inorganics
language:en
Short-container-title:Inorganics

Author:

Umba-Tsumbu Evariste¹^ORCID,Hammouda Ahmed N.¹²^ORCID,Jackson Graham Ellis¹^ORCID

Affiliation:

1. Department of Chemistry, University of Cape Town, Cape Town 7701, South Africa

2. Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi 16063, Libya

Abstract

Membrane permeability of copper complexes with potential anti-inflammatory activity were measured using an artificial membrane in a modified Franz cell. Using CuCl2 as the control, all the ligands tested enhanced the diffusion of copper, with enhancement factors ranging from 2 to 7. Octanol/water partition coefficients (log Ko/w) were measured and correlated with the permeability coefficients (Kp). In addition, chemical speciation was used to determine the predominant complex in solution at physiological pH. No correlation was found between the measured permeability coefficients and either molecular weight (MW) or log Ko/w.

Funder

the National Research Foundation of South Africa

the University of Cape Town Research Committee

the Eric Abraham Foundation

Publisher

MDPI AG

Subject

Inorganic Chemistry

Link

https://www.mdpi.com/2304-6740/11/5/179/pdf

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