Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl4(H2O)2]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation

Author:

Bourwina Mansoura1,Walha Sandra1,Krayem Najeh2,Badraoui Riadh34ORCID,Brahmi Faten5,Alshammari Wejdan M.3,Snoussi Mejdi3ORCID,Turnbull Mark M.6ORCID,Roisnel Thierry7ORCID,Naïli Houcine1ORCID

Affiliation:

1. Laboratoire Physico-Chimie de l’Etat Solide, Département de Chimie, Faculté des Sciences de Sfax, Université de Sfax, B.P. 1171, Sfax 3000, Tunisia

2. Laboratory of Biochemistry and Engineering of Lipases, National School of Engineering of Sfax (ENIS), University of Sfax, Sfax 3000, Tunisia

3. Laboratory of General Biology, Department of Biology, University of Ha’il, Ha’il 81451, Saudi Arabia

4. Section of Histology-Cytology, Faculty of Medicine of Tunis, University of Tunis El Manar, La Rabta-Tunis 1007, Tunisia

5. Laboratory of Organic Chemistry, Department of Chemistry, University of Ha’il, Ha’il 81451, Saudi Arabia

6. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA

7. Institut des Sciences Chimiques de Rennes, UMR 6226 CNRS, Campus de Beaulieu France, Université Rennes, F-35000 Rennes, France

Abstract

A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C5H14N2)[MnCl4(H2O)2] crystallizes in the centrosymmetric space group P2/c of the monoclinic system. The crystal structure of the Mn(II) complex is characterized by an alternation of 0-dimensional organic and inorganic stacks linked together by N/O-H…Cl and N-H…O hydrogen bonds, which lead to a three-dimensional supramolecular architecture. In this structure, the inorganic layer is built up by independent anionic moieties combining the two isomers cis/trans of [MnCl4(H2O)2]2−. The thermal decomposition was studied by TGA-DTA techniques. The optical band gap and Urbach energy were obtained by Tauc’s equation. The direct and indirect band gap values are found to be 4.58 and 4.44 eV, respectively. Weak antiferromagnetic interactions are present in the molecule under study, according to magnetic measurements. An agar well diffusion technique was used to assess the synthetic compound’s biological activity, and the results showed that it has potent antibacterial (Gram-positive and Gram-negative) properties. Interestingly, the synthesized compound also displayed antilipase activity. These biological activities have been confirmed by the bioavailability and pharmacokinetic analyses.

Funder

Deanship of Scientific Research at University of Ha’il

Publisher

MDPI AG

Subject

Inorganic Chemistry

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