Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass-Reference-Cited by-同舟云学术

Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass

Published:2024-05-16 Issue:10 Volume:13 Page:2943
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Serraino Giuseppe Filiberto¹^ORCID,Bolignano Davide²^ORCID,Jiritano Federica¹^ORCID,Coppolino Giuseppe³^ORCID,Napolitano Désirée¹^ORCID,Zicarelli Mariateresa²,Pizzini Patrizia⁴,Cutrupi Sebastiano⁴,Testa Alessandra⁴,Spoto Belinda⁴,Andreucci Michele³^ORCID,Mastroroberto Pasquale¹^ORCID,Serra Raffaele²⁵^ORCID

Affiliation:

1. Department of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy

2. Department of Medical and Surgical Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy

3. Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy

4. Italian National Council of Research (CNR)—Institute of Clinical Physiology, 89100 Reggio Calabria, Italy

5. Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy

Abstract

Background: Biomarkers development for prognostication or prediction of perioperative myocardial disease is critical for the evolution of treatment options in patients undergoing cardiac surgery. The aim of our prospective monocentric study was to investigate the role of selenoprotein 1 (SEEP 1) as a potential biomarker for assessing the risk of myocardial injury after cardiac surgery. Methods: Circulating SEPP1 was measured in the blood of 45 patients before surgery and at 4 h, 8 h and 12 h after CPB by enzyme-linked immunosorbent assay (ELISA); (3) Results: circulating SEPP-1 levels measured 4 h after surgery were strongly correlated with CK-MB levels measured at 48 h (R = 0.598, p < 0.0001) and at 72 h (R = 0.308, p = 0.05). Close correlations were also found between 4 h SEPP-1 and Hs-c troponin values measured at 24 h (R = 0.532, p < 0.0001), 48 h (R = 0.348, p = 0.01) and 72 h (R = 0.377, p = 0.02), as well as with cardiopulmonary bypass (CPB) (R = 0.389, p = 0.008) and cross-clamp time (R = 0.374, p = 0.001); (4) Conclusions: Early SEPP1 measurement after CPB may hold great potential for identifying cardiac surgery patients at risk of developing perioperative myocardial injury.

Publisher

MDPI AG

Link

https://www.mdpi.com/2077-0383/13/10/2943/pdf

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