Positive Effects of a Resveratrol-Based Nutraceutical in Association with Surgical Scleroembolization: A Pilot Retrospective Clinical Trial

Author:

Italiano Emilio1,Ceccarelli Giada2,Italiano Giovanna3,Piazza Fulvio4,Iannitti Rossana Giulietta2,Puglisi Tiziana4

Affiliation:

1. Centro Genesi, Via Libertà, 90144 Palermo, Italy

2. S&R Farmaceutici S.p.A., 06083 Bastia Umbra, Italy

3. Policlinico Brescia, Unità Operativa di Urologia, 25128 Brescia, Italy

4. Azienda Ospedaliera “Cervello-Villa Sofia“, 90146 Palermo, Italy

Abstract

Background: Varicocele still today represents a common cause of infertility in young men. The treatment strategy remains a surgical approach such as scleroembolization; however, the complete restoration of spermatic parameters afterward requires an average of six or more months to fully regain optimal seminal parameters. Recently, many studies have demonstrated the beneficial effects of Resveratrol in male fertility, given its potential anti-inflammatory, antiapoptotic, and mitochondrial effects. Therefore, Resveratrol-based nutraceuticals could be promising as an adjuvant to mitigate subfertility in patients with varicocele. Methods: In the present study, we retrospectively analyzed the effects of the administration of a Resveratrol-based nutraceutical after the scleroembolization procedure. The improvement of sperm quality in terms of number, motility, and morphology were considered to be the study’s main endpoints. A spreadsheet program was used for data analysis, and a p-value of <0.05 was considered significant. Results: We found a statistically significant improvement in the spermatic parameters (sperm count and total motility) and an increase in normal sperm after only 4 months of treatment. The supplementation with a Resveratrol-based nutraceutical associated with the surgical procedure showed encouraging results if compared to data from a control group and the results reported in the literature linked to scleroembolization practice alone. In fact, there was a clear improvement in the seminal parameters at 4 months. Conclusions: This suggests the positive impact of the Resveratrol-based nutraceutical in synergizing with scleroembolization in reducing the time needed to fully recover sperm function.

Publisher

MDPI AG

Reference40 articles.

1. Varicocèle et infertilité masculine [Varicocele and male infertility];Huyghe;Prog. Urol.,2023

2. Leslie, S.W., Sajjad, H., and Siref, L.E. (2023). StatPearls, StatPearls Publishing.

3. (2024, January 5–8). EAU Guidelines. Proceedings of the EAU Annual Congress, Paris, France.

4. Determination of the time for improvement in semen parameters after varicocelectomy;Pazir;Andrologia,2021

5. Can varicocelectomy significantly change the way couples use assisted reproductive technologies?;Cayan;J. Urol.,2002

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3