Gout Basic Research: 2023 in Review

Author:

Muntiu Maria1,Joosten Leo A. B.12ORCID,Crişan Tania O.12

Affiliation:

1. Department of Medical Genetics Iuliu Hațieganu, University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania

2. Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

Abstract

Gout is a prevalent form of inflammatory arthritis caused by the crystallization of uric acid in the joints and soft tissues, leading to acute, painful attacks. Activation of the NLRP3 inflammasome in mononuclear cells, along with inflammasome-independent pathways, is responsible for the inflammatory phenotype in gout. Research into the different aspects of gout pathophysiology and potential treatment options is ongoing. This review highlights some of the basic research published in the 12 months following the 2022 Gout, Hyperuricemia, and Crystal-Associated Disease Network (G-CAN) conference and focuses on mechanisms of inflammation, encompassing pro- and anti-inflammatory pathways, as well as the exploration of various biological systems, such as single-cell transcriptomics, proteomics, metabolomics, and microbiome analyses.

Funder

Romanian Ministry of Investments and European Projects

Publisher

MDPI AG

Reference37 articles.

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3. The NLRP3 inflammasome—Interleukin 1 pathway as a therapeutic target in gout;Szekanecz;Arch. Biochem. Biophys.,2019

4. The role of interleukin-1 family members in hyperuricemia and gout;Liu;Jt. Bone Spine,2020

5. Asymptomatic hyperuricaemia: A silent activator of the innate immune system;Joosten;Nat. Rev. Rheumatol.,2020

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