Affiliation:
1. Department of Medical Genetics Iuliu Hațieganu, University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
2. Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands
Abstract
Gout is a prevalent form of inflammatory arthritis caused by the crystallization of uric acid in the joints and soft tissues, leading to acute, painful attacks. Activation of the NLRP3 inflammasome in mononuclear cells, along with inflammasome-independent pathways, is responsible for the inflammatory phenotype in gout. Research into the different aspects of gout pathophysiology and potential treatment options is ongoing. This review highlights some of the basic research published in the 12 months following the 2022 Gout, Hyperuricemia, and Crystal-Associated Disease Network (G-CAN) conference and focuses on mechanisms of inflammation, encompassing pro- and anti-inflammatory pathways, as well as the exploration of various biological systems, such as single-cell transcriptomics, proteomics, metabolomics, and microbiome analyses.
Funder
Romanian Ministry of Investments and European Projects
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