Abstract
Sickle cell anaemia is one of the most common hemoglobinopathies worldwide and an important public health problem in Brazil. This study evaluated the prevalence of sickle cell anaemia and its traits in newborns from the Amazon-Savanna Transition Region in the state of Maranhão, Brazil. A cross-sectional study was carried out, based on data from neonatal screening tests performed in 2013–2015 in Maranhão. The Hardy-Weinberg theorem was applied to analyse the frequency of expected homozygotes based on HbSS phenotype. A spatial-temporal distribution analysis was performed to delimit the regions with the greatest number of newborn cases with sickle cell anaemia. Of 283,003 newborns, 162 were found to have sickle cell anaemia, while 10,794 had a sickle cell trait, with a prevalence of 0.05% and 3.8%, respectively. The prevalence of expected homozygotes was higher in the North Region and in the state capital of Maranhão. This study may contribute to existing social and public health actions or the creation of new strategies for sickle cell disease in endemic areas in Brazil to improve the quality of life.
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health
Reference29 articles.
1. Cognitive profile of children with sickle cell anemia compared to healthy controls
2. Doença Falciforme: Condutas Básicas para Tratamento,2012
3. Hematologia Laboratorial: Teoria e Procedimentos;Da Silva,2016
4. Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia;Aleluia;Lipids Health Dis.,2017
5. Sickle cell trait: Heterozygous for the hemoglobin S;Murão;Rev. Bras. Hematol. Hemoter.,2007
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献