Author:
Kroņkalne Rasma,Beļaunieks Rūdolfs,Turks Māris
Abstract
SN2 rection between 4-(tert-butyldimethylsilyl)hex-5-yn-1-yl 4-methylbenzenesulfonate and NaN3 in DMF at 80 °C provided (6-azidohex-1-yn-3-yl)(tert-butyl)dimethylsilane intermediate, which underwent in situ intramolecular thermal Huisgen azide–alkyne cycloaddition reaction. This one-pot process gave 4-(tert-butyldimethylsilyl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridine in 78% yield.
Funder
Riga Technical University
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Reference21 articles.
1. The Chemistry of the [1,2,3]Triazolo[1,5-a]pyridines: An Update
2. The Chemistry of [1,2,3]Triazolo[1,5- a] pyridines
3. Preparation of Cycloalkylamino Nitrogen Heterocycles as Potassium Channel Modulators for the Treatment and Prevention of Disorders;Eriksen;U.S. Patent,2020
4. Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies
5. Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献