Abstract
The body of work described in this research paper evaluates the compatibility between Fenbendazole (Fen), which is a broad-spectrum anthelmintic with promising antitumor activity, and three polymeric excipients commonly applied in pharmaceutical dosage forms. The assessment of binary mixtures was performed by differential scanning calorimetry and thermogravimetric analysis/derivative thermogravimetry to predict physical and/or chemical interactions, followed by X-ray diffraction spectroscopy (XRD), Fourier transform infrared spectroscopy (FTIR), and high-performance liquid chromatography (HPLC) to confirm or exclude any interactions. Thermal studies suggested the presence of interactions between Fen and P 407, PCL, and PLA. To validate these data, XRD showed that Fen is compatible with PCL and PLA, suggesting some interaction with P 407. FTIR demonstrated that PCL and PLA can establish physical interactions with Fen; moreover, it suggested that P 407 interacts not only physically but also chemically, which was later proved by HPLC to be only new intermolecular interactions. This work supports the further application of P 407, PCL, and PLA for the development of new medicinal and veterinary formulations containing Fen, since they do not affect the physical and chemical characteristics of the active ingredient and consequently its bioavailability and therapeutic efficacy.
Funder
Irish Research Council
President Seed Fund from TUS: Midlands and Midwest
Reference45 articles.
1. National Center for Biotechnology Information (2022, August 01). PubChem Compound Summary for CID 3334, Fenbendazole, Available online: https://pubchem.ncbi.nlm.nih.gov/compound/Fenbendazole.
2. Field evaluation of the efficacy of fenbendazole in captive wild ruminants;Goossens;Vet. Record,2005
3. Fenbendazole controls in vitro growth, virulence potential, and animal infection in the Cryptococcus model;Joffe;Antimicrob. Agents Chemother.,2020
4. Dewormer drug fenbendazole has antiviral effects on BoHV-1 productive infection in cell cultures;Chang;J. Vet. Sci.,2020
5. Fenbendazole as a potential anticancer drug;Duan;Anticancer Res.,2013
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献