Beat-to-Beat Tracking of Pulse Pressure and Its Respiratory Variation Using Heart Sound Signal in Patients Undergoing Liver Transplantation

Abstract

Purpose: To investigate the possibility of esophageal phonocardiography as a monitor for invasively measured pulse pressure (PP) and its respiratory variation (PPV) in patients undergoing liver transplantation. Methods: In 24 liver transplantation recipients, all hemodynamic parameters, including PP and PPV, were measured during five predetermined surgical phases. Simultaneously, signals of esophageal heart sounds (S1, S2) were identified, and S1–S2 interval (phonocardiographic systolic time, PST) and its respiratory variation (PSV) within a 20-s window were calculated. Beat-to-beat correlation between PP and its corresponding PST was assessed during each time window, according to the surgical phases. To compare PPV and PSV along with 5 phases (a total of 120 data pairs), Pearson correlation was conducted. Results: Beat-to-beat PST values were closely correlated with their corresponding 3360 pairs of PP values (median r = 0.568 [IQR 0.246–0.803]). Compared with the initial phase of surgery, correlation coefficients were significantly lower during the reperfusion period (median r = 0.717 [IQR 0.532–0.886] vs. median r = 0.346 [IQR 0.037–0.677]; p = 0.002). The correlation between PSV and PPV showed similar variation according to the surgical phases (r = 0.576 to 0.689, p < 0.05, for pre-reperfusion; 0.290 to 0.429 for the post-reperfusion period). Conclusions: Continuous monitoring of intraoperative PST with an esophageal stethoscope has the potential to act as an indirect estimator of beat-to-beat arterial PP. Moreover, PSV appears to exhibit a trend similar to that of PPV with moderate accuracy. However, variation according to the surgical phase limits the merit of the current results, thereby necessitating cautious interpretation.