Nanotechnology Promoting the Development of Products from the Biodiversity of the Asteraceae Family

Author:

Yien Raíssa Mara Kao12,Matos Ana Paula dos Santos2ORCID,Gomes Anne Caroline Candido1,Garófalo Denise de Abreu2,Santos-Oliveira Ralph3ORCID,Simas Naomi Kato1ORCID,Ricci-Júnior Eduardo2ORCID

Affiliation:

1. Laboratory of Natural Products and Biological Assays, Department of Natural and Food Products, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil

2. Laboratory of Pharmaceutical Nanotechnology, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-901, Brazil

3. Laboratory of Nanoradiopharmacy and Synthesis of Novel Radiopharmaceuticals, Nuclear Engineering Institute Brazilian Nuclear Energy Commission, Rio de Janeiro 21941-906, Brazil

Abstract

Biodiversity is a hallmark of the Asteraceae family. Several species are known for their pharmacological potential. The search for new substances has permeated the chemistry of natural products for years. However, the development of a final product is still a challenge. Plant extracts have physicochemical characteristics that sometimes hinder administration, requiring a formulation. In this context, nanotechnology emerges as a tool to improve the pharmacokinetic parameters of several pharmacologically active substances. Nanoemulsions, liposomes, and nanoparticles are used to carry the active ingredients and thus improve therapeutic action, especially for substances with solubility and absorption problems. This paper aimed at compiling all the studies that used nanotechnology to develop formulations from species of the Asteraceae family from 2010 to 2021 in a literature review. The search showed that nanoemulsions are the most developed formulation associated with essential oils. The use of nanotechnology promoted an improvement in the pharmacokinetic parameters of active substances.

Funder

Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State (FAPERJ)—Cientista do Nosso Estado

Apoio aos Programas e Cursos de Pós-graduação Stricto Sensu do Estado do Rio de Janeiro

Rede NanoSaude

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)—Bolsa Produtividade em Pesquisa PQ-2

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Reference55 articles.

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