B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development

Author:

Li Qian1,Wubshet Ashenafi Kiros12ORCID,Wang Yang1,Heath Livio3,Zhang Jie4

Affiliation:

1. Key Laboratory of Veterinary Etiological Biology, National/WOAH Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China

2. Department of Veterinary Basics and Diagnostic Sciences, College of Veterinary Science, Mekelle University, Mekelle 2084, Tigray, Ethiopia

3. Transboundary Animal Diseases: Vaccine Production Programme, Onderstepoort Veterinary Research Institute, Agricultural Research Council, Pretoria 0110, South Africa

4. Hebei Key Laboratory of Preventive Veterinary Medicine, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China

Abstract

Failure of cross-protection among interserotypes and intratypes of foot-and-mouth disease virus (FMDV) is a big threat to endemic countries and their prevention and control strategies. However, insights into practices relating to the development of a multi-epitope vaccine appear as a best alternative approach to alleviate the cross-protection-associated problems. In order to facilitate the development of such a vaccine design approach, identification and prediction of the antigenic B and T cell epitopes along with determining the level of immunogenicity are essential bioinformatics steps. These steps are well applied in Eurasian serotypes, but very rare in South African Territories (SAT) Types, particularly in serotype SAT2. For this reason, the available scattered immunogenic information on SAT2 epitopes needs to be organized and clearly understood. Therefore, in this review, we compiled relevant bioinformatic reports about B and T cell epitopes of the incursionary SAT2 FMDV and the promising experimental demonstrations of such designed and developed vaccines against this serotype.

Funder

Key Research and Development Program of Gansu Province

Project Funds

Hebei Normal University of Science and Technology

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

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