Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia-Reference-Cited by-全球学者库

Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia

Published:2024-01-09 Issue:1 Volume:17 Page:85
ISSN:1424-8247
Container-title:Pharmaceuticals
language:en
Short-container-title:Pharmaceuticals

Author:

Kalinovic Raluka¹²,Pascariu Andrei²,Vlad Gabriela²,Nitusca Diana³⁴^ORCID,Sălcudean Andreea⁵,Sirbu Ioan³⁴^ORCID,Marian Catalin³⁴^ORCID,Enatescu Virgil²⁶

Affiliation:

1. Doctoral School, University of Medicine and Pharmacy Victor Babes Timisoara, 300041 Timisoara, Romania

2. Eduard Pamfil Psychiatric Clinic, Timisoara County Emergency Clinical Hospital, 300425 Timisoara, Romania

3. Department of Biochemistry, University of Medicine and Pharmacy Victor Babes Timisoara, 300041 Timisoara, Romania

4. Center for Complex Networks Science, Victor Babes University of Medicine and Pharmacy, Pta Eftimie Murgu Nr. 2, 300041 Timisoara, Romania

5. Discipline of Sociobiology, Department of Ethics and Social Sciences, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540136 Targu Mures, Romania

6. Discipline of Psychiatry, Department of Neurosciences, University of Medicine and Pharmacy Victor Babes Timisoara, 300041 Timisoara, Romania

Abstract

The expression of GPCRs has been associated with schizophrenia, and their expression may induce morphological changes in brain regions responsible for schizophrenia and disease-specific behavioral changes. The articles included in this review were selected using keywords and databases of scientific research websites. The expressions of GPRs have different involvements in schizophrenia, some increase the risk while others provide protection, and they may also be potential targets for new treatments. Proper evaluation of these factors is essential to have a better therapeutic response with a lower rate of chronicity and thus improve the long-term prognosis.

Publisher

MDPI AG

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://www.mdpi.com/1424-8247/17/1/85/pdf

Reference41 articles.

1. Schizophrenia;Carpenter;N. Engl. J. Med.,1994

2. Schizophrenia as a Complex Trait: Evidence from a Meta-analysis of Twin Studies;Sullivan;Arch. Gen. Psychiatry,2003

3. Treatment of schizophrenia in the 21st Century: Beyond the neurotransmitter hy-pothesis;Rogers;Expert. Rev. Neurother.,2009

4. Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients;Mattai;Am. J. Psychiatry,2011

5. Longitudinal volume reductions in people at high genetic risk of schizophrenia as they develop psychosis;McIntosh;Biol. Psychiatry,2011