Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil-Reference-Cited by-同舟云学术

Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil

Published:2023-02-20 Issue:2 Volume:15 Page:585
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

de Menezes Mariane Talon¹^ORCID,Moreira Filipe Romero Rebello¹²,Whittaker Charles²,Santos Franciele Martins³,Queiroz Daniel Costa³^ORCID,Geddes Victor³,Fonseca Paula Luize Camargos³^ORCID,de Jesus Jaqueline Góes⁴⁵^ORCID,Mendes-Oliveira Franciane⁴^ORCID,Reis-Souza Valquíria⁴,Santos Bibiana⁶^ORCID,Zauli Danielle Alves Gomes⁷,de Lima Aline Brito⁷^ORCID,de Brito Mendonça Cristiane⁷^ORCID,Alvim Luige Biciati⁷^ORCID,do Prado Silva Joice⁷^ORCID,Malta Frederico Scott Varella⁷^ORCID,de Souza Ferreira Alessandro Clayton⁷,Faria Nuno R.²⁴⁸,Sabino Ester Cerdeira⁴⁵^ORCID,Aguiar Renato Santana¹³⁹^ORCID

Affiliation:

1. Laboratory of Molecular Virology, Institute of Biology, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil

2. MRC Centre for Global Infectious Disease Analysis, Imperial College London, London SW7 2BX, UK

3. Laboratory of Integrative Biology, Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270, Brazil

4. Institute of Tropical Medicine, Faculty of Medicine, University of São Paulo, São Paulo 04023, Brazil

5. Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo 04023, Brazil

6. Mendelics Genomic Analysis, São Paulo 04023, Brazil

7. Pardini Group, Research and Development Department, Belo Horizonte 31270, Brazil

8. Department of Zoology, University of Oxford, Oxford OX3 7BN, UK

9. D’OR Institute of Research and Teaching, Rio de Janeiro 21941-901, Brazil

Abstract

Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG.

Funder

Instituto Mulheres do Brasil and Rede Corona-ômica BR MCTI/FINEP

MEC/CAPES 118

FINEP

UFMG-NB3, FINEP

Medical Research Council-São Paulo Research Foundation (FAPESP) CADDE partnership award

Instituto Todos pela Saúde-ITpS

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Sir Henry Wellcome Postdoctoral Fellowship

CNPq

Publisher

MDPI AG