Experimental Validation of Realistic Measurement Setup for Quantitative UWB-Guided Hyperthermia Temperature Monitoring

Abstract

Hyperthermia induces slight temperature increase of 4–8 °C inside the tumor, making it more responsive to radiation and drugs, thereby improving the outcome of the oncological treatment. To verify the level of heat in the tumor and to avoid damage of the healthy tissue, methods for non-invasive temperature monitoring are needed. Temperature estimation by means of microwave imaging is of great interest among the scientific community. In this paper, we present the results of experiments based on ultra-wideband (UWB) M-sequence technology. Our temperature estimation approach uses temperature dependency of tissue dielectric properties and relation of UWB images to the reflection coefficient on the boundary between tissue types. The realistic measurement setup for neck cancer hyperthermia considers three antenna arrangements. Data are processed with Delay and Sum beamforming and Truncated Singular Value Decomposition. Two types of experiments are presented in this paper. In the first experiment, relative permittivity of subsequently replaced tumor mimicking material is estimated, and in the second experiment, real temperature change in the tumor imitate is monitored. The results showed that the presented approach allows for qualitative as well as quantitative permittivity and temperature estimation. The frequency range for temperature estimation, preferable antenna configurations, and limitations of the method are indicated.